Difference between revisions of "Skin"
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(→Microscopic evaluation: +seborrheic keratosis) |
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{{Fixation}} | {{Fixation}} | ||
− | + | ==Dark skin focalities== | |
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[[File:Dark skin focalities.jpg|thumb|center|Dark skin focalities (in this case, from top left and clockwise: Spitz nevus, seborrheic keratosis, elevated melanocytic nevus and melanoma)]] | [[File:Dark skin focalities.jpg|thumb|center|Dark skin focalities (in this case, from top left and clockwise: Spitz nevus, seborrheic keratosis, elevated melanocytic nevus and melanoma)]] | ||
Skin with one or more areas that are darker than the surroundings. | Skin with one or more areas that are darker than the surroundings. | ||
− | + | ===Microscopic evaluation=== | |
[[File:Pie chart of incidence and malignancy of pigmented skin lesions.png|thumb|370px|Various diagnoses of pigmented skin lesions, by relative incidence upon biopsy, and malignancy potential.]] | [[File:Pie chart of incidence and malignancy of pigmented skin lesions.png|thumb|370px|Various diagnoses of pigmented skin lesions, by relative incidence upon biopsy, and malignancy potential.]] | ||
Evaluation is largely based on the relative incidence and malignancy of various differential diagnoses (see pie chart). Main approaches are: | Evaluation is largely based on the relative incidence and malignancy of various differential diagnoses (see pie chart). Main approaches are: | ||
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*Systematic | *Systematic | ||
− | + | ====Pattern recognition==== | |
<gallery> | <gallery> | ||
File:Histopathology of melanocytic nevus.jpg|Melanocytic nevus | File:Histopathology of melanocytic nevus.jpg|Melanocytic nevus | ||
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</gallery> | </gallery> | ||
− | + | ====Systematic==== | |
By their relative incidences, one practical approach is: | By their relative incidences, one practical approach is: | ||
*Is it a dysplastic (melanocytic) nevus? If not: | *Is it a dysplastic (melanocytic) nevus? If not: |
Revision as of 08:31, 18 September 2019
Author:
Mikael Häggström [note 1]
Contents
Fixation
- Generally: Buffered 4% formaldehyde.[1]
- Suspected immunologic disease:[2] Fixation for immunofluorescence, with for example Michel's solution.[1] For details, see immunofluorescense of skin tissues
- REDIRECT Template:Fixation - general notes
Dark skin focalities
Skin with one or more areas that are darker than the surroundings.
Microscopic evaluation
Evaluation is largely based on the relative incidence and malignancy of various differential diagnoses (see pie chart). Main approaches are:
- Direct pattern recognition
- Systematic
Pattern recognition
Systematic
By their relative incidences, one practical approach is:
- Is it a dysplastic (melanocytic) nevus? If not:
- Is it a melanoma? If not:
- Compare to patterns of various other possibilities.
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-09.
- ↑ Page 678 in: Chhabra, Seema; Minz, RanjanaWalker; Saikia, Biman (2012). "Immunofluorescence in dermatology ". Indian Journal of Dermatology, Venereology, and Leprology 78 (6): 677. doi: . ISSN 0378-6323. Archived from the original. .
Image sources