Stomach biopsy for Helicobacter pylori

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Author: Mikael Häggström [note 1]

Microscopic evaluation

Dozens of the curved bacteria fill the lumen of a gastric foveola on H&E stain.

Look for:

  • Helicobacter pylori-like bacteria in the lumen, as curved, spirochete-like bacteria, generally in the superficial mucus layer and along microvilli of epithelial cells.[1]
  • Associated inflammation, typically a chronic inflammatory infiltrate with germinal centers (follicular gastritis), and plasma cells in lamina propria.[1][notes 1] There should be at least 3 plasma cells facing each other to make a diagnosis of chronic gastritis.

Example report

Chronic gastritis without H. pylori-like organisms should be described as non-specific:

Mild chronic gastritis, which is non-specific.

Negative for H. pylori-like organisms on H&E stain.


  1. Plasma cells and lymphocytes are normally found in the lamina propria of the small and large intestine, but is abnormal in the stomach.
  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. 1.0 1.1 Elliot Weisenberg. Stomach - Infections - Helicobacter pylori. Pathology Outlines. Topic Completed: 1 August 2012. Minor changes: 1 September 2020

Image sources