Difference between revisions of "Template:Breast cancer staging"

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===Staging===
 
===Staging===
 +
Stage by the TNM system as follows.
 +
 +
Also, look for any angiolymphatic invasion. If present, check whether it reaches outside the tumor, and if so, how far.<ref name=Stanford/>
 +
 
====Primary Tumor (T)====
 
====Primary Tumor (T)====
 
'''T'''umor&nbsp;– Depends on the tumor at the primary site of origin, as follows:<ref name=Alkabban2019>Originally copied from {{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK482286/|title=Cancer, Breast|author=Fadi M. Alkabban; Troy Ferguson|website=[[National Center for Biotechnology Information]]}} Last Update: June 4, 2019. [http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International License]</ref>  
 
'''T'''umor&nbsp;– Depends on the tumor at the primary site of origin, as follows:<ref name=Alkabban2019>Originally copied from {{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK482286/|title=Cancer, Breast|author=Fadi M. Alkabban; Troy Ferguson|website=[[National Center for Biotechnology Information]]}} Last Update: June 4, 2019. [http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International License]</ref>  
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===Regional Lymph Nodes (N)===
 
===Regional Lymph Nodes (N)===
 
Lymph '''N'''ode&nbsp;– The lymph node values depend on the number, size and location of breast cancer cell deposits in various regional lymph nodes, such as the armpit (axillary lymph nodes), the collar area (supraclavicular lymph nodes), and inside the chest (internal mammary lymph nodes.)<ref name="pmid3347753">{{cite journal |vauthors=Scatarige JC, Fishman EK, Zinreich ES, Brem RF, Almaraz R |title=Internal mammary lymphadenopathy in breast carcinoma: CT appraisal of anatomic distribution |journal=Radiology |volume=167 |issue=1 |pages=89–91 |date=April 1988 |pmid=3347753 |doi= 10.1148/radiology.167.1.3347753|url=}}</ref><ref name="pmid2217975">{{cite journal |vauthors=Scatarige JC, Boxen I, Smathers RL |title=Internal mammary lymphadenopathy: imaging of a vital lymphatic pathway in breast cancer |journal=Radiographics |volume=10 |issue=5 |pages=857–70 |date=September 1990 |pmid=2217975 |doi= 10.1148/radiographics.10.5.2217975|url=}}</ref> Each stage is as follows:<ref name=Alkabban2019/>
 
Lymph '''N'''ode&nbsp;– The lymph node values depend on the number, size and location of breast cancer cell deposits in various regional lymph nodes, such as the armpit (axillary lymph nodes), the collar area (supraclavicular lymph nodes), and inside the chest (internal mammary lymph nodes.)<ref name="pmid3347753">{{cite journal |vauthors=Scatarige JC, Fishman EK, Zinreich ES, Brem RF, Almaraz R |title=Internal mammary lymphadenopathy in breast carcinoma: CT appraisal of anatomic distribution |journal=Radiology |volume=167 |issue=1 |pages=89–91 |date=April 1988 |pmid=3347753 |doi= 10.1148/radiology.167.1.3347753|url=}}</ref><ref name="pmid2217975">{{cite journal |vauthors=Scatarige JC, Boxen I, Smathers RL |title=Internal mammary lymphadenopathy: imaging of a vital lymphatic pathway in breast cancer |journal=Radiographics |volume=10 |issue=5 |pages=857–70 |date=September 1990 |pmid=2217975 |doi= 10.1148/radiographics.10.5.2217975|url=}}</ref> Each stage is as follows:<ref name=Alkabban2019/>
*N0: There is some nuance to the official definitions for N0 disease, which includes N0(i+) which refers to Isolated Tumor Cell clusters (ITC), which are small clusters of cells not greater than 0.2&nbsp;mm, or single tumor cells, or a cluster of fewer than 200 cells in a single histologic cross-section, whether detected by routine histology or [[immunohistochemistry]]; N0 also includes N0(mol-), in which regional lymph nodes have no metastases histologically, but have positive molecular findings (RT-PCR).
+
*N0: There is some nuance to the official definitions for N0 disease, which includes:
*N1: Mobile ipsilateral axillary nodes
+
:* N0(i+) : Isolated Tumor Cell clusters (ITC),<ref name=Stanford/> which are small clusters of cells not greater than 0.2&nbsp;mm, or single tumor cells, or a cluster of fewer than 200 cells in a single histologic cross-section, whether detected by routine histology or [[immunohistochemistry]];  
*N2: Fixed/matted ipsilateral axillary nodes
+
:* N0(mol-): regional lymph nodes have no metastases histologically, but have positive molecular findings (RT-PCR).  
 +
*N1: Mobile ipsilateral axillary nodes. Lymph node clusters 0.2 - 2.0 mm can be called "micrometastasis". At least one carcinoma focus over 2.0 mm is called "Lymph node metastasis". If one node qualifies as metastasis, count all other nodes even with smaller foci as metastases as well.<ref name=Stanford/>
 +
Critical numbers of involved nodes: 1-3, 4-9, and 10 and over. Note any extranodal extension.<ref name=Stanford/>
 +
*N2: Fixed/matted ipsilateral axillary nodes.
 
*N3
 
*N3
 
:*N3a – Ipsilateral infraclavicular nodes
 
:*N3a – Ipsilateral infraclavicular nodes
:*N3b – Ipsilateral int mammary nodes
+
:*N3b – Ipsilateral internal mammary nodes
 
:*N3c – Ipsilateral supraclavicular nodes
 
:*N3c – Ipsilateral supraclavicular nodes
  

Revision as of 09:42, 4 October 2019

Staging

Stage by the TNM system as follows.

Also, look for any angiolymphatic invasion. If present, check whether it reaches outside the tumor, and if so, how far.[1]

Primary Tumor (T)

Tumor – Depends on the tumor at the primary site of origin, as follows:[2]

  • T1a: 0.1 to 0.5 cm
  • T1b: 0.5 to 1.0 cm
  • T1c: 1.0 to 2.0 cm
  • T2: 2 to 5 cm
  • T3: Larger than 5 cm
  • T4
  • T4a: Chest wall involvement
  • T4b: Skin involvement
  • T4c: Both 4a and 4b
  • T4d: Inflammatory breast cancer, a clinical circumstance where typical skin changes involve at least a third of the breast.

Regional Lymph Nodes (N)

Lymph Node – The lymph node values depend on the number, size and location of breast cancer cell deposits in various regional lymph nodes, such as the armpit (axillary lymph nodes), the collar area (supraclavicular lymph nodes), and inside the chest (internal mammary lymph nodes.)[3][4] Each stage is as follows:[2]

  • N0: There is some nuance to the official definitions for N0 disease, which includes:
  • N0(i+) : Isolated Tumor Cell clusters (ITC),[1] which are small clusters of cells not greater than 0.2 mm, or single tumor cells, or a cluster of fewer than 200 cells in a single histologic cross-section, whether detected by routine histology or immunohistochemistry;
  • N0(mol-): regional lymph nodes have no metastases histologically, but have positive molecular findings (RT-PCR).
  • N1: Mobile ipsilateral axillary nodes. Lymph node clusters 0.2 - 2.0 mm can be called "micrometastasis". At least one carcinoma focus over 2.0 mm is called "Lymph node metastasis". If one node qualifies as metastasis, count all other nodes even with smaller foci as metastases as well.[1]

Critical numbers of involved nodes: 1-3, 4-9, and 10 and over. Note any extranodal extension.[1]

  • N2: Fixed/matted ipsilateral axillary nodes.
  • N3
  • N3a – Ipsilateral infraclavicular nodes
  • N3b – Ipsilateral internal mammary nodes
  • N3c – Ipsilateral supraclavicular nodes

Distant Metastases (M)

  • M0: No clinical or radiographic evidence of distant metastases
  • M0(i+): Molecularly or microscopically detected tumor cells in circulating blood, bone marrow or non-regional nodal tissue, no larger than 0.2 mm, and without clinical or radiographic evidence or symptoms or signs of metastases, and which, perhaps counter-intuitively, does not change the stage grouping, as staging for in M0(i+) is done according to the T and N values
  • M1: Distant detectable metastases as determined by classic clinical and radiographic means, and/or metastasis that are histologically larger than 0.2 mm.

Overall stage

A combination of T, N and M, as follows:[2]

  • Stage 0: Tis
  • Stage I: T1N0
  • Stage II: T2N0, T3N0 T0N1, T1N1, or T2N1
  • Stage III: Invasion into skin and/or ribs, matted lymph nodes, T3N1, T0N2, T1N2, T2N2, T3N2, AnyT N3, T4 any N, locally advanced breast cancer
  • Stage IV: M1, advanced breast cancer

Notes


Main page

References

  1. 1.0 1.1 1.2 1.3 Cite error: Invalid <ref> tag; no text was provided for refs named Stanford
  2. 2.0 2.1 2.2 Originally copied from Fadi M. Alkabban; Troy Ferguson. Cancer, Breast. National Center for Biotechnology Information. Last Update: June 4, 2019. Creative Commons Attribution 4.0 International License
  3. "Internal mammary lymphadenopathy in breast carcinoma: CT appraisal of anatomic distribution ". Radiology 167 (1): 89–91. April 1988. doi:10.1148/radiology.167.1.3347753. PMID 3347753. 
  4. "Internal mammary lymphadenopathy: imaging of a vital lymphatic pathway in breast cancer ". Radiographics 10 (5): 857–70. September 1990. doi:10.1148/radiographics.10.5.2217975. PMID 2217975. 

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