Difference between revisions of "Template:Colorectal adenocarcinoma - microscopy criteria"
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↑ 1.0 1.1 1.2 1.3 1.4 1.5 Robert V Rouse. Adenocarcinoma of the Colon and Rectum. Stanford University School of Medicine. Original posting/updates: 1/31/10, 7/15/11, 11/12/11
↑ 2.0 2.1 Li, Lianhuang; Jiang, Weizhong; Yang, Yinghong; Chen, Zhifen; Feng, Changyin; Li, Hongsheng; Guan, Guoxian; Chen, Jianxin (2014). "Identification of dirty necrosis in colorectal carcinoma based on multiphoton microscopy
". Journal of Biomedical Optics 19 (6): 066008. doi:. ISSN 1083-3668.
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===Microscopy criteria for colorectal adenocarcinoma=== | ===Microscopy criteria for colorectal adenocarcinoma=== | ||
| + | [[File:Colorectal adenocarcinoma, not otherwise specified.jpg|thumb|250px|Colorectal adenocarcinoma, not otherwise specified]] | ||
*A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has: | *A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has: | ||
*Severe '''cytologic atypia'''<ref name=Stanford-criteria>{{cite web|url=http://surgpathcriteria.stanford.edu/gitumors/colorectal-adenocarcinoma/|title=Adenocarcinoma of the Colon and Rectum|author=Robert V Rouse|website=Stanford University School of Medicine}} Original posting/updates: 1/31/10, 7/15/11, 11/12/11</ref> | *Severe '''cytologic atypia'''<ref name=Stanford-criteria>{{cite web|url=http://surgpathcriteria.stanford.edu/gitumors/colorectal-adenocarcinoma/|title=Adenocarcinoma of the Colon and Rectum|author=Robert V Rouse|website=Stanford University School of Medicine}} Original posting/updates: 1/31/10, 7/15/11, 11/12/11</ref> | ||
Revision as of 08:51, 14 January 2020
Microscopy criteria for colorectal adenocarcinoma
- A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has:
- Severe cytologic atypia[1]
- Cribriform architecture, consisting of juxtaposed gland lumens without stroma in between, with loss of cell polarity. Rarely, they have foci of squamous differentiation (morules).[1]
- This should be distinguished from cases where piles of well-differentiated mucin-producing cells appear cribriform. In such piles, nuclei show regular polarity with apical mucin, and their nuclei are not markedly enlarged.[1]
- Invasive adenocarcinoma commonly displays:[1]
- Varying degrees of gland formation with tall columnar cells
- Frequenty desmoplasia
- Dirty necrosis, consisting of extensive central necrosis with granular eosinophilic karyorrhectic cell detritus.[1][2] It is located within the glandular lumina,[2] or often with a garland of cribriform glands in their vicinity.[1]
