Template:Colorectal adenocarcinoma - microscopy criteria
Microscopy criteria for colorectal adenocarcinoma
- Lesion is at least a "high grade intramucosal neoplasia" (high grade dysplasia) have:
- Severe cytologic atypia[1]
- Cribriform architecture, consisting of juxtaposed gland lumens without stroma in between, with loss of cell polarity. Rarely, they have foci of squamous differentiation (morules).[1]
- This should be distinguished from cases where piles of well-differentiated mucin-producing cells appear cribriform. In such piles, nuclei show regular polarity with apical mucin, and their nuclei are not markedly enlarged.[1]
- Invasive adenocarcinoma commonly displays:[1]
- Varying degrees of gland formation with tall columnar cells
- Frequenty desmoplasia
- Dirty necrosis, consisting of extensive central necrosis with granular eosinophilic karyorrhectic debris. Garland of cribriform glands are frequently found in their vicinity.