Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"

From patholines.org
Jump to navigation Jump to search
m (removed)
Line 10: Line 10:
 
File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis.
 
File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis.
 
File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
 
File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
File:BCC with squamous cell metaplasia with HE and BerEP4 staining, vertical layout.jpg|'''[[Basal-cell carcinoma]] with squamous cell metaplasia''': Basal-cell carcinoma is generally distinguishable by for example relatively less cytoplasm, palisading, cleft formations and absence of horn cyst formation. Yet, a high prevalence means a relatively high incidence of borderline cases, such as those with squamous cell metaplasia (pictured). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (pictured).
+
File:BCC with squamous cell metaplasia with HE and BerEP4 staining.jpg|'''[[Basal-cell carcinoma]] with squamous cell metaplasia''': Basal-cell carcinoma is generally distinguishable by for example relatively less cytoplasm, palisading, cleft formations and absence of horn cyst formation. Yet, a high prevalence means a relatively high incidence of borderline cases, such as those with squamous cell metaplasia (pictured). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (pictured).
 
File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC.
 
File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC.
 
File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia. Image also shows folding artifacts (white arrows).  
 
File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia. Image also shows folding artifacts (white arrows).  

Revision as of 04:41, 5 March 2020

Author: Mikael Häggström [note 1]

Squamous cell-like skin proliferations: Differential diagnosis

Main differential diagnoses and their characteristics:[1]

Notes

  1. Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
    - Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi:10.4103/2229-5178.182354. ISSN 2229-5178. 
  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:10.3390/biomedicines5040071. ISSN 2227-9059.  - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."

Image sources