Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"
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File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis. | File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis. | ||
File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding). | File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding). | ||
− | File:BCC with squamous cell metaplasia with HE and BerEP4 staining | + | File:BCC with squamous cell metaplasia with HE and BerEP4 staining.jpg|'''[[Basal-cell carcinoma]] with squamous cell metaplasia''': Basal-cell carcinoma is generally distinguishable by for example relatively less cytoplasm, palisading, cleft formations and absence of horn cyst formation. Yet, a high prevalence means a relatively high incidence of borderline cases, such as those with squamous cell metaplasia (pictured). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (pictured). |
File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC. | File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC. | ||
File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia. Image also shows folding artifacts (white arrows). | File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia. Image also shows folding artifacts (white arrows). |
Revision as of 04:41, 5 March 2020
Author:
Mikael Häggström [note 1]
Contents
Squamous cell-like skin proliferations: Differential diagnosis
Main differential diagnoses and their characteristics:[1]
Invasive squamous-cell carcinoma of the skin: Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
Squamous-cell carcinoma in situ (Bowen’s disease): Atypical keratinocytes at every layer of epidermis.
Actinic keratosis: Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
Basal-cell carcinoma with squamous cell metaplasia: Basal-cell carcinoma is generally distinguishable by for example relatively less cytoplasm, palisading, cleft formations and absence of horn cyst formation. Yet, a high prevalence means a relatively high incidence of borderline cases, such as those with squamous cell metaplasia (pictured). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (pictured).
- *''Buschke–Löwenstein tumor'' is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
- *''Carcinoma cuniculatum'' is a characteristic form of verrucous squamous cell carcinoma on the sole.
Inverted follicular keratosis:[notes 1]: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
Seborrheic keratosis: Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.
Notes
- ↑ Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
- Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi: . ISSN 2229-5178.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi: . ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
Image sources