Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"
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File:Micrograph of microcystic adnexal carcinoma - superficial follicular keratin-filled cysts.jpg|'''Adnexal carcinomas''': Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. | File:Micrograph of microcystic adnexal carcinoma - superficial follicular keratin-filled cysts.jpg|'''Adnexal carcinomas''': Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. | ||
File:Micrograph of cutaneous adenosquamous carcinoma - 40x.jpg|'''Adenosquamous carcinoma''': Mixed glandular and squamous differentiation. | File:Micrograph of cutaneous adenosquamous carcinoma - 40x.jpg|'''Adenosquamous carcinoma''': Mixed glandular and squamous differentiation. | ||
− | File:Micrograph of penile verrucous carcinoma - 20x and 200x.jpg|'''Verrucous squamous cell carcinoma'''<ref group="notes> | + | File:Micrograph of penile verrucous carcinoma - 20x and 200x.jpg|'''Verrucous squamous cell carcinoma'''<ref group="notes>- ''Buschke–Löwenstein tumor'' is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.<br>- ''Carcinoma cuniculatum'' is a characteristic form of verrucous squamous cell carcinoma on the sole.</ref>: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot. |
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− | </ref>: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot. | ||
File:Inverted follicular keratosis - Low and high magnification.jpg|'''Inverted follicular keratosis''':<ref group="notes">Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.<br>- {{cite journal|last1=Karadag|first1=AyseSerap|last2=Ozlu|first2=Emin|last3=Uzuncakmak|first3=TugbaKevser|last4=Akdeniz|first4=Necmettin|last5=Cobanoglu|first5=Bengu|last6=Oman|first6=Berkant|title=Inverted follicular keratosis successfully treated with imiquimod|journal=Indian Dermatology Online Journal|volume=7|issue=3|year=2016|pages=177|issn=2229-5178|doi=10.4103/2229-5178.182354}}</ref>: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. | File:Inverted follicular keratosis - Low and high magnification.jpg|'''Inverted follicular keratosis''':<ref group="notes">Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.<br>- {{cite journal|last1=Karadag|first1=AyseSerap|last2=Ozlu|first2=Emin|last3=Uzuncakmak|first3=TugbaKevser|last4=Akdeniz|first4=Necmettin|last5=Cobanoglu|first5=Bengu|last6=Oman|first6=Berkant|title=Inverted follicular keratosis successfully treated with imiquimod|journal=Indian Dermatology Online Journal|volume=7|issue=3|year=2016|pages=177|issn=2229-5178|doi=10.4103/2229-5178.182354}}</ref>: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. | ||
File:Histopathology of seborrheic keratosis.jpg|'''[[Seborrheic keratosis]]''': Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. | File:Histopathology of seborrheic keratosis.jpg|'''[[Seborrheic keratosis]]''': Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. |
Revision as of 04:42, 5 March 2020
Author:
Mikael Häggström [note 1]
Contents
Squamous cell-like skin proliferations: Differential diagnosis
Main differential diagnoses and their characteristics:[1]
Invasive squamous-cell carcinoma of the skin: Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
Squamous-cell carcinoma in situ (Bowen’s disease): Atypical keratinocytes at every layer of epidermis.
Actinic keratosis: Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
Basal-cell carcinoma with squamous cell metaplasia: Basal-cell carcinoma is generally distinguishable by for example relatively less cytoplasm, palisading, cleft formations and absence of horn cyst formation. Yet, a high prevalence means a relatively high incidence of borderline cases, such as those with squamous cell metaplasia (pictured). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (pictured).
Verrucous squamous cell carcinoma[notes 1]: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot.
Inverted follicular keratosis:[notes 2]: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
Seborrheic keratosis: Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.
Notes
- ↑ - Buschke–Löwenstein tumor is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
- Carcinoma cuniculatum is a characteristic form of verrucous squamous cell carcinoma on the sole. - ↑ Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
- Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi: . ISSN 2229-5178.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi: . ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
Image sources