Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"
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− | ===Squamous cell-like proliferations: Differential diagnosis=== | + | <noinclude> |
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− | + | |author1=[[User:Mikael Häggström|Mikael Häggström]] | |
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− | | Invasive [[squamous-cell carcinoma of the skin]] | + | ===Squamous cell-like skin proliferations: Differential diagnosis=== |
− | |- | + | Main differential diagnoses and their characteristics:<ref name="PaolinoDonati2017">Initially copied from: {{cite journal|last1=Paolino|first1=Giovanni|last2=Donati|first2=Michele|last3=Didona|first3=Dario|last4=Mercuri|first4=Santo|last5=Cantisani|first5=Carmen|title=Histology of Non-Melanoma Skin Cancers: An Update|journal=Biomedicines|volume=5|issue=4|year=2017|pages=71|issn=2227-9059|doi=10.3390/biomedicines5040071}} - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref> |
− | + | <gallery mode=packed heights=200> | |
− | + | File:Micrograph of invasive squamous cell carcinoma - 150x.jpg|'''Invasive [[squamous-cell carcinoma of the skin]]''': Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. | |
− | + | File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis. | |
− | | | + | File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding). |
− | + | File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC. | |
− | | | + | File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia with mainly hypereosinophilia and nuclear pleomorphism. Image also shows folding artifacts (white arrows). |
− | + | File:Micrograph of microcystic adnexal carcinoma - superficial follicular keratin-filled cysts.jpg|'''Adnexal carcinomas''': Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. | |
− | + | File:Micrograph of cutaneous adenosquamous carcinoma - 40x.jpg|'''Adenosquamous carcinoma''': Mixed glandular and squamous differentiation. | |
− | | Adnexal carcinomas | + | File:Verruca Vulgaris (5242100122).jpg|'''Verruca vulgaris''': Marked hyperkeratosis and papillomatosis. Rete ridges slope inward at the borders of the lesion. |
− | + | File:Micrograph of penile verrucous carcinoma - 20x and 200x.jpg|'''Verrucous squamous cell carcinoma'''<ref group="notes>- ''Buschke–Löwenstein tumor'' is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.<br>- ''Carcinoma cuniculatum'' is a characteristic form of verrucous squamous cell carcinoma on the sole.</ref>: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot. | |
− | | Adenosquamous carcinoma | + | File:Inverted follicular keratosis - Low and high magnification.jpg|'''Inverted follicular keratosis''':<ref group="notes">Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.<br>- {{cite journal|last1=Karadag|first1=AyseSerap|last2=Ozlu|first2=Emin|last3=Uzuncakmak|first3=TugbaKevser|last4=Akdeniz|first4=Necmettin|last5=Cobanoglu|first5=Bengu|last6=Oman|first6=Berkant|title=Inverted follicular keratosis successfully treated with imiquimod|journal=Indian Dermatology Online Journal|volume=7|issue=3|year=2016|pages=177|issn=2229-5178|doi=10.4103/2229-5178.182354}}</ref>: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. |
− | |- | + | File:Histopathology of seborrheic keratosis.jpg|'''[[Seborrheic keratosis]]''': Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. |
− | | Verrucous squamous cell carcinoma<ref group="notes> | + | File:High-magnification micrograph of oral bowenoid papulosis.jpg|'''Bowenoid papulosis''': Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease. |
− | + | File:Melanoma resembling a squamous cell carcinoma.jpg|A '''[[melanoma]]''' may have relatively plentiful eosinophilic cytoplasm, and be seemingly continuous with the squamous epithelium (at left in image), thus resembling a squamous cell carcinoma. However, the nesting of cells at right in the image is more characteristic of a melanoma. | |
− | + | File:Micrograph of squamous cell carcinoma metastasis to the skin.jpg|'''Metastasis''': Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. Squamous-cell carcinoma metastasis from lungs to the skin is pictured. | |
− | | | + | </gallery><noinclude> |
− | | Inverted follicular keratosis || Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. | + | {{Bottom}} |
− | | | + | </noinclude> |
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− | |||
− | | Bowenoid papulosis | ||
− | | | ||
− | | Metastasis | ||
− |
Revision as of 11:50, 22 July 2021
Author:
Mikael Häggström [note 1]
Contents
Squamous cell-like skin proliferations: Differential diagnosis
Main differential diagnoses and their characteristics:[1]
Invasive squamous-cell carcinoma of the skin: Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
Squamous-cell carcinoma in situ (Bowen’s disease): Atypical keratinocytes at every layer of epidermis.
Actinic keratosis: Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
Verrucous squamous cell carcinoma[notes 1]: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot.
Inverted follicular keratosis:[notes 2]: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
Seborrheic keratosis: Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.
A melanoma may have relatively plentiful eosinophilic cytoplasm, and be seemingly continuous with the squamous epithelium (at left in image), thus resembling a squamous cell carcinoma. However, the nesting of cells at right in the image is more characteristic of a melanoma.
Notes
- ↑ - Buschke–Löwenstein tumor is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
- Carcinoma cuniculatum is a characteristic form of verrucous squamous cell carcinoma on the sole. - ↑ Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
- Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi: . ISSN 2229-5178.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi: . ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
Image sources