Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"

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===Squamous cell-like proliferations: Differential diagnosis===
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===Squamous cell-like skin proliferations: Differential diagnosis===
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Main differential diagnoses and their characteristics:<ref name="PaolinoDonati2017">Initially copied from: {{cite journal|last1=Paolino|first1=Giovanni|last2=Donati|first2=Michele|last3=Didona|first3=Dario|last4=Mercuri|first4=Santo|last5=Cantisani|first5=Carmen|title=Histology of Non-Melanoma Skin Cancers: An Update|journal=Biomedicines|volume=5|issue=4|year=2017|pages=71|issn=2227-9059|doi=10.3390/biomedicines5040071}} - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref>
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<gallery mode=packed heights=200>
! Condition<ref name="PaolinoDonati2017">Initially copied from: {{cite journal|last1=Paolino|first1=Giovanni|last2=Donati|first2=Michele|last3=Didona|first3=Dario|last4=Mercuri|first4=Santo|last5=Cantisani|first5=Carmen|title=Histology of Non-Melanoma Skin Cancers: An Update|journal=Biomedicines|volume=5|issue=4|year=2017|pages=71|issn=2227-9059|doi=10.3390/biomedicines5040071}} - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref> !! Characteristics<ref name="PaolinoDonati2017"/> !! Image
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File:Micrograph of invasive squamous cell carcinoma - 150x.jpg|'''Invasive [[squamous-cell carcinoma of the skin]]''': Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
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File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis.
| Invasive [[squamous-cell carcinoma of the skin]] || Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. || [[File:Micrograph of invasive squamous cell carcinoma - 150x.jpg|190px]]
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File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
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File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC.
| [[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]] || Atypical keratinocytes at every layer of epidermis. || [[File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|190px]]
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File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia with mainly hypereosinophilia and nuclear pleomorphism. Image also shows folding artifacts (white arrows).  
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File:Micrograph of microcystic adnexal carcinoma - superficial follicular keratin-filled cysts.jpg|'''Adnexal carcinomas''': Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features.
| [[Actinic keratosis]] || Atypical keratinocytes confined to the epidermis. || [[File:Micrograph of actinic keratosis - low magnification.jpg|190px]]
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File:Micrograph of cutaneous adenosquamous carcinoma - 40x.jpg|'''Adenosquamous carcinoma''': Mixed glandular and squamous differentiation.
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File:Verruca Vulgaris (5242100122).jpg|'''Verruca vulgaris''': Marked hyperkeratosis and papillomatosis. Rete ridges slope inward at the borders of the lesion.
| Keratoacanthoma || Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. Highly differentiated SCC. || [[File:Keratoacanthoma (2197016163).jpg|190px]]
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File:Micrograph of penile verrucous carcinoma - 20x and 200x.jpg|'''Verrucous squamous cell carcinoma'''<ref group="notes>- ''Buschke–Löwenstein tumor'' is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.<br>- ''Carcinoma cuniculatum'' is a characteristic form of verrucous squamous cell carcinoma on the sole.</ref>: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot.
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File:Inverted follicular keratosis - Low and high magnification.jpg|'''Inverted follicular keratosis''':<ref group="notes">Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.<br>- {{cite journal|last1=Karadag|first1=AyseSerap|last2=Ozlu|first2=Emin|last3=Uzuncakmak|first3=TugbaKevser|last4=Akdeniz|first4=Necmettin|last5=Cobanoglu|first5=Bengu|last6=Oman|first6=Berkant|title=Inverted follicular keratosis successfully treated with imiquimod|journal=Indian Dermatology Online Journal|volume=7|issue=3|year=2016|pages=177|issn=2229-5178|doi=10.4103/2229-5178.182354}}</ref>: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
| Adnexal carcinomas || Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. || [[File:Micrograph of microcystic adnexal carcinoma - superficial follicular keratin-filled cysts.jpg|190px]]
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File:Histopathology of seborrheic keratosis.jpg|'''[[Seborrheic keratosis]]''': Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.  
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File:High-magnification micrograph of oral bowenoid papulosis.jpg|'''Bowenoid papulosis''': Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease.  
| Adenosquamous carcinoma || Mixed glandular and squamous differentiation. || [[File:Micrograph of cutaneous adenosquamous carcinoma - 40x.jpg|190px]]
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File:Melanoma resembling a squamous cell carcinoma.jpg|A '''[[melanoma]]''' may have relatively plentiful eosinophilic cytoplasm, and be seemingly continuous with the squamous epithelium (at left in image), thus resembling a squamous cell carcinoma. However, the nesting of cells at right in the image is more characteristic of a melanoma.
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File:Micrograph of squamous cell carcinoma metastasis to the skin.jpg|'''Metastasis''': Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. Squamous-cell carcinoma metastasis from lungs to the skin is pictured.
| Verrucous squamous cell carcinoma<ref group="notes>
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</gallery><noinclude>
*''Buschke–Löwenstein tumor'' is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
 
*''Carcinoma cuniculatum'' is a characteristic form of verrucous squamous cell carcinoma on the sole.
 
</ref> || Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot. || [[File:Micrograph of penile verrucous carcinoma - 20x.jpg|190px]] [[File:Micrograph of penile verrucous carcinoma - 200x.jpg|190px]]
 
|-
 
| Inverted follicular keratosis<ref group="notes">Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.<br>- {{cite journal|last1=Karadag|first1=AyseSerap|last2=Ozlu|first2=Emin|last3=Uzuncakmak|first3=TugbaKevser|last4=Akdeniz|first4=Necmettin|last5=Cobanoglu|first5=Bengu|last6=Oman|first6=Berkant|title=Inverted follicular keratosis successfully treated with imiquimod|journal=Indian Dermatology Online Journal|volume=7|issue=3|year=2016|pages=177|issn=2229-5178|doi=10.4103/2229-5178.182354}}</ref> || Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. || [[File:Inverted follicular keratosis 1 (3059309003).jpg|190px]] [[File:Inverted follicular keratosis 3 (3060145758).jpg|190px]]
 
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| [[Seborrheic keratosis]] || Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. || [[File:Histopathology of seborrheic keratosis.jpg|190px]]
 
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| Bowenoid papulosis || Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease. || [[File:Low-magnification micrograph of oral bowenoid papulosis.jpg|190px]] [[File:High-magnification micrograph of oral bowenoid papulosis.jpg|190px]]
 
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| Metastasis || Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. || [[File:Micrograph of squamous cell carcinoma metastasis to the skin.jpg|thumb|170px|Squamous-cell carcinoma metastasis from lungs to the skin]]
 
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Revision as of 11:50, 22 July 2021

Author: Mikael Häggström [note 1]

Squamous cell-like skin proliferations: Differential diagnosis

Main differential diagnoses and their characteristics:[1]

Notes

  1. - Buschke–Löwenstein tumor is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
    - Carcinoma cuniculatum is a characteristic form of verrucous squamous cell carcinoma on the sole.
  2. Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
    - Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi:10.4103/2229-5178.182354. ISSN 2229-5178. 
  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:10.3390/biomedicines5040071. ISSN 2227-9059.  - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."

Image sources