Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"
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| − | ! Condition<ref name="PaolinoDonati2017">Initially copied from: {{cite journal|last1=Paolino|first1=Giovanni|last2=Donati|first2=Michele|last3=Didona|first3=Dario|last4=Mercuri|first4=Santo|last5=Cantisani|first5=Carmen|title=Histology of Non-Melanoma Skin Cancers: An Update|journal=Biomedicines|volume=5|issue=4|year=2017|pages=71|issn=2227-9059|doi=10.3390/biomedicines5040071}} - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref> !! Characteristics<ref name="PaolinoDonati2017"/> | + | ! Condition<ref name="PaolinoDonati2017">Initially copied from: {{cite journal|last1=Paolino|first1=Giovanni|last2=Donati|first2=Michele|last3=Didona|first3=Dario|last4=Mercuri|first4=Santo|last5=Cantisani|first5=Carmen|title=Histology of Non-Melanoma Skin Cancers: An Update|journal=Biomedicines|volume=5|issue=4|year=2017|pages=71|issn=2227-9059|doi=10.3390/biomedicines5040071}} - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref> !! Characteristics<ref name="PaolinoDonati2017"/> !! Image |
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| − | | Invasive [[squamous-cell carcinoma of the skin]] || Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. | + | | Invasive [[squamous-cell carcinoma of the skin]] || Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. || [[File:Micrograph of invasive squamous cell carcinoma - 150x.jpg|190px]] |
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| − | | [[Actinic keratosis]] || Atypical keratinocytes confined on basal layer. | + | | [[Actinic keratosis]] || Atypical keratinocytes confined on basal layer. || [[File:Micrograph of actinic keratosis - low magnification.jpg|190px]] |
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| Bowen || Atypical keratinocytes at every layer of epidermis. | | Bowen || Atypical keratinocytes at every layer of epidermis. | ||
Revision as of 07:29, 25 October 2019
Squamous cell-like proliferations: Differential diagnosis
| Condition[1] | Characteristics[1] | Image |
|---|---|---|
| Invasive squamous-cell carcinoma of the skin | Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. | 
|
| Actinic keratosis | Atypical keratinocytes confined on basal layer. | 
|
| Bowen | Atypical keratinocytes at every layer of epidermis. | |
| Keratoacanthoma | Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. Highly differentiated SCC. | |
| Queyrat’s erytroplasia | As Bowen, but in the mucosa. | |
| Adnexal carcinomas | Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. | |
| Adenosquamous carcinoma | Mixed glandular and squamous differentiation. | |
| Verrucous squamous cell carcinoma[notes 1] | Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes | |
| Epithelioma cuniculatum | Squamous-cell carcinoma of the foot. Histologically is characterized hyperkeratosis, acanthosis with an undulating, densely keratinized, well differentiated squamous epithelium, deeply penetrating the soft tissues. | |
| Inverted follicular keratosis | Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. | |
| Seborrheic keratosis | Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. | |
| Bowenoid papulosis | Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease. | |
| Metastasis | Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. |
- ↑ 1.0 1.1 Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:. ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
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