Template:Squamous-cell like skin proliferations - differential diagnosis
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Squamous cell-like proliferations: Differential diagnosis
Condition[1] | Characteristics[1] |
---|---|
Invasive squamous-cell carcinoma of the skin | Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread. |
Actinic keratosis | Atypical keratinocytes confined on basal layer. |
Bowen | Atypical keratinocytes at every layer of epidermis. |
Keratoacanthoma | Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. Highly differentiated SCC. |
Queyrat’s erytroplasia | As Bowen, but in the mucosa. |
Adnexal carcinomas | Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features. |
Adenosquamous carcinoma | Mixed glandular and squamous differentiation. |
Verrucous squamous cell carcinoma[notes 1] | Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes |
Epithelioma cuniculatum | Squamous-cell carcinoma of the foot. Histologically is characterized hyperkeratosis, acanthosis with an undulating, densely keratinized, well differentiated squamous epithelium, deeply penetrating the soft tissues. |
Inverted follicular keratosis | Sharply circumscribed endophytic verrucous proliferation with prominent squamous features. |
Seborrheic keratosis | Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present. |
Bowenoid papulosis | Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease. |
Metastasis | Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. |
- ↑ 1.0 1.1 Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi: . ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
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