Template:Squamous-cell like skin proliferations - differential diagnosis

From patholines.org
Jump to navigation Jump to search

Squamous cell-like proliferations: Differential diagnosis

Condition[1] Characteristics[1]
Invasive squamous-cell carcinoma of the skin Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
Actinic keratosis Atypical keratinocytes confined on basal layer.
Bowen Atypical keratinocytes at every layer of epidermis.
Keratoacanthoma Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. Highly differentiated SCC.
Queyrat’s erytroplasia As Bowen, but in the mucosa.
Adnexal carcinomas Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features.
Adenosquamous carcinoma Mixed glandular and squamous differentiation.
Verrucous squamous cell carcinoma[notes 1] Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes
Epithelioma cuniculatum Squamous-cell carcinoma of the foot. Histologically is characterized hyperkeratosis, acanthosis with an undulating, densely keratinized, well differentiated squamous epithelium, deeply penetrating the soft tissues.
Inverted follicular keratosis Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
Seborrheic keratosis Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.
Bowenoid papulosis Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease.
Metastasis Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation.
  1. 1.0 1.1 Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:10.3390/biomedicines5040071. ISSN 2227-9059.  - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."


Cite error: <ref> tags exist for a group named "notes", but no corresponding <references group="notes"/> tag was found, or a closing </ref> is missing