Difference between revisions of "Testicle"

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(Comprehensiveness)
(→‎Evaluation: Described)
 
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File:Relative incidences of testicular tumors.png|Relative incidences of testicular tumors.{{MH}}<ref>{{cite journal| author=Gill MS, Shah SH, Soomro IN, Kayani N, Hasan SH| title=Morphological pattern of testicular tumors. | journal=J Pak Med Assoc | year= 2000 | volume= 50 | issue= 4 | pages= 110-3 | pmid=10851829 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10851829  }}</ref>
 
File:Relative incidences of testicular tumors.png|Relative incidences of testicular tumors.{{MH}}<ref>{{cite journal| author=Gill MS, Shah SH, Soomro IN, Kayani N, Hasan SH| title=Morphological pattern of testicular tumors. | journal=J Pak Med Assoc | year= 2000 | volume= 50 | issue= 4 | pages= 110-3 | pmid=10851829 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10851829  }}</ref>
File:Seminoma (microscopic, H&E) (268018290).jpg|'''Seminoma''', with typical features:<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/testisseminomas.html|title=Testis & paratestis.Germ cell tumors. Seminoma|author=Michelle R. Downes, M.D.|website=Pathology Outlines}} Last author update: 7 January 2020. Last staff update: 26 January 2021</ref><br>Sheets or lobular configuration with fibrous septae.<br>Pale cytoplasm (but may be eosinophilic).<br>Well defined cell membranes<br>
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File:Histopathology of seminoma.png |Classical '''seminoma''', with typical features:{{MH}}<ref>Reference for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/testisseminomas.html|title=Testis & paratestis - Seminoma|author=Michelle R. Downes, M.D.|website=Pathology Outlines}} Last author update: 7 January 2020. Last staff update: 19 April 2022</ref>
Nuclei being polygonal, and may have a flat edge giving.<br>Prominent central nucleoli.
 
 
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{{Further|Tumor evaluation}}
 
{{Further|Tumor evaluation}}

Latest revision as of 16:24, 30 December 2022

Author: Mikael Häggström [note 1]

Comprehensiveness

On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Gross processing

Triage

Usual steps:[1]

  • Weigh the specimen.
  • Measure:
  • The size of the testis in 3 dimensions
  • The spermatic cord length and diameter
  • Ink the tunica vaginalis.
  • Cut through tunica vaginalis with scissors
  • Bisect the testis in the plane of the epididymis.
  • If any tumor:
  • Photograph the cut surface.
  • Measure the size of the tumor in 3 dimensions
  • Describe the gross appearance.
  • Measure the distance of the tumor from the tunica vaginalis
  • Note tumor extension: up to, into, or through the tunica albuginea or vaginalis.
  • Measure the distance of the tumor from the epididymis and spermatic cord, and note any epididymal and spermatic cord involvement.
  • Describe the remaining testicular parenchyma.
  • If the specimen is large, serially section perpendicular to the long axis.

Tissue selection

Generally including the following:[1]

  • The proximal spermatic cord margin en face[note 2].
  • For any tumor:
  • At least 1 section per cm of tumor, including the closest penetration of tunica albuginea/vaginalis and epididymis.
  • Grossly different areas of tumor to determine which components are present (in case of potential mixed germ cell tumor).
  • Additional sections of the spermatic cord
  • Normal (uninvolved) testis.
  • Any found lymph nodes

In case of orchiectomy for undescended testis, submit the entire testicular parenchyma to evaluate for GCNIS (germ cell neoplasia in situ).[1]

Evaluation

Look mainly for:

  • Tumors.

Further information: Tumor evaluation

  • ((Optionally, disorders of spermatogenesis.))
Spermatogenesis pathologies.png

Reporting

Example in a normal case:

Right testicle and spermatic cord, radical orchiectomy:
Benign testis(, negative for malignancy).

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. En face means that the section is tangential to the region of interest (such as a lesion) of a specimen. Further information: Gross_processing#Cutting

Main page

References

  1. 1.0 1.1 1.2 Nicole Cipriani. Testis. The University of Chicago Department of Pathology. Retrieved on 2021-03-31.
  2. Gill MS, Shah SH, Soomro IN, Kayani N, Hasan SH (2000). "Morphological pattern of testicular tumors. ". J Pak Med Assoc 50 (4): 110-3. PMID 10851829. Archived from the original. . 
  3. Reference for findings: Michelle R. Downes, M.D.. Testis & paratestis - Seminoma. Pathology Outlines. Last author update: 7 January 2020. Last staff update: 19 April 2022

Image sources