Difference between revisions of "Thyroid cytology"
m (''') |
m (''') |
||
Line 46: | Line 46: | ||
File:Cytology of benign follicular epithelial cells.jpg|Cytology of benign follicular epithelial cells (Bethesda category II), Pap stain, showing cells with significant nuclear pleomorphism but otherwise insignificant features. | File:Cytology of benign follicular epithelial cells.jpg|Cytology of benign follicular epithelial cells (Bethesda category II), Pap stain, showing cells with significant nuclear pleomorphism but otherwise insignificant features. | ||
File:Pie chart of relative incidences of thyroid cancers.png|Relative incidences of '''malignant''' thyroid tumors. | File:Pie chart of relative incidences of thyroid cancers.png|Relative incidences of '''malignant''' thyroid tumors. | ||
− | File:Cytology | + | File:Cytology suspicious for Hürthle cell neoplasm, annotated.png|Cytopathology '''suspicious for Hürthle cell neoplasm''' (Bethesda category IV), Pap stain. However, it cannot distinguish Hürthle cell adenoma from Hürthle cell carcinoma, which requires histopathologic sections to see transcapsular or vascular invasion. Hürthle cell hyperplasia (as seen in Hashimoto's thyroiditis) may show moderate variation in nuclear sizes and prominent nucleoli, but further findings favoring Hürthle cell neoplasm include a large number of Hürthle cells, and discohesiveness.<ref>Image by Mikael Häggström, MD. References for findings:<br>- {{cite web|url=https://www.pathologyoutlines.com/topic/thyroidhurthlecellneoplasm.html|title=Hürthle cell neoplasm|website=Pathology Outlines|author=Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D.}} Last author update: 7 May 2020. Last staff update: 12 May 2022<br>- {{cite journal| author=Shawky M, Sakr M| title=Hurthle Cell Lesion: Controversies, Challenges, and Debates. | journal=Indian J Surg | year= 2016 | volume= 78 | issue= 1 | pages= 41-8 | pmid=27186039 | doi=10.1007/s12262-015-1381-x | pmc=4848220 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848220/}}</ref> |
</gallery> | </gallery> | ||
{{Bottom}} | {{Bottom}} |
Revision as of 19:06, 21 September 2022
Author:
Mikael Häggström [note 1]
Adequacy
A minimum number of 6 clusters with 10 cells each has been arbitrary established to assume adequacy for a definitive diagnosis.[1] The presence of characteristic cells may still confer a definitive diagnosis, but otherwise, the report will simply state inadequate number of cells.
Risk stratification
Classify findings as per the Bethesda system:
Category | Description[2] | Example report |
---|---|---|
I | Non diagnostic/unsatisfactory | |
II | Benign (colloid and follicular cells) | Thyroid aspiration, right upper pole:
|
III | Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) (follicular or lymphoid cells with atypical features) | Thyroid aspiration, right mid pole:
|
IV | Follicular nodule/suspicious follicular nodule (cell crowding, micro follicles, dispersed isolated cells, scant colloid) | |
V | Suspicious for malignancy | |
VI | Malignant |
- Cytology suspicious for Hürthle cell neoplasm, annotated.png
Cytopathology suspicious for Hürthle cell neoplasm (Bethesda category IV), Pap stain. However, it cannot distinguish Hürthle cell adenoma from Hürthle cell carcinoma, which requires histopathologic sections to see transcapsular or vascular invasion. Hürthle cell hyperplasia (as seen in Hashimoto's thyroiditis) may show moderate variation in nuclear sizes and prominent nucleoli, but further findings favoring Hürthle cell neoplasm include a large number of Hürthle cells, and discohesiveness.[3]
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Michael, Claire W.; Pang, Yijun; Pu, Robert T.; Hasteh, Farnaz; Griffith, Kent A. (2007). "Cellular adequacy for thyroid aspirates prepared by ThinPrep: How many cells are needed? ". Diagnostic Cytopathology 35 (12): 792–797. doi: . ISSN 87551039.
- ↑ "The bethesda system for reporting thyroid cytopathology: interpretation and guidelines in surgical treatment ". Indian Journal of Otolaryngology and Head and Neck Surgery 64 (4): 305–311. December 2012. doi: . PMID 24294568.
- ↑ Image by Mikael Häggström, MD. References for findings:
- Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D.. Hürthle cell neoplasm. Pathology Outlines. Last author update: 7 May 2020. Last staff update: 12 May 2022
- Shawky M, Sakr M (2016). "Hurthle Cell Lesion: Controversies, Challenges, and Debates. ". Indian J Surg 78 (1): 41-8. doi: . PMID 27186039. PMC: 4848220. Archived from the original. .
Image sources