The main condition of interest in urinary bladder cytologies and biopsies is bladder cancer.
Gross reporting of transurethral resections
|Container A. Labeled "bladder tumor". The specimen is received in formalin and consists of multiple fragments of tan-gray, friable soft tissue measuring about __ x __ x __ cm in aggregate. The specimen is entirely submitted for microscopic examination in __ cassettes.|
Low grade urothelial carcinoma: Urothelium is thickened but only slightly atypical and has maintained polarity.
High grade urothelial carcinoma: Loss of polarity and severe abnormal cytology.
In contrast, an inverted urothelial papilloma has smooth surface with minimal to absent exophytic component, is well circumscribed with smooth base, and has no obvious infiltration and no/minimal cytologic atypia.
Squamous cell carcinoma of the urinary bladder. Further information: Urothelial versus squamous cell carcinoma
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- It may be sufficient to submit representative sections that include the muscular layer, if grossly identified. Yet, many departments require submission of the entire specimen regardless, so if unsure, that is the safe choice.
- Tissue from transurethral resections are generally very brittle and may escape the openings of a conventional cassette.
- . Types of Bladder Cancer: TCC & Other Variants. CTCA.
- Monika Roychowdhury. Bladder, ureter & renal pelvis - Urothelial neoplasms - noninvasive - Inverted urothelial papilloma. Pathology Outlines. Topic Completed: 1 December 2014. Minor changes: 3 December 2020