Usual ductal hyperplasia
Author:
Mikael Häggström [note 1]
Contents
Gross examination
As per:
or mastectomy.
Microscopic evaluation
Usual ductal hyperplasia is typically a cohesive proliferation with haphazard, jumbled cell arrangement or streaming growth pattern. Cells have mild variation in cellular and nuclear size and shape.[1]
- Differential diagnosis
In contrast to usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH) displays:[1]
- Increased amounts of pale eosinophilic to amphophilic cytoplasm with conspicuous cell borders
- Atypical architectural patterns, including cribriform spaces, Roman arches, trabecular bars and micropapillae
If uncertain, immunohistochemistry can be performed:[1]
| Usual ductal hyperplasia (UDH) | Atypical ductal hyperplasia (ADH) | |
| High molecular weight keratins | Mosaic to occasionally diffuse | Negative |
| Estrogen receptor | Heterogenous staining | Diffusely positive |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 1.2 Sofia Lérias, M.D., Melinda Lerwill, M.D.. Usual ductal hyperplasia. Pathology Outlines. Last author update: 11 February 2021. Last staff update: 25 April 2022
Image sources
