Generally, the main finding to look for in biopsies from the esophagus is intestinalized mucosa (Barret's esophagus), which is defined as the presence of columnar epithelium with goblet cells. A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered. The mucin usually indents the nucleus.
Non-dysplastic Barret's esophagus (NDBE). Yellow arrow in a indicates goblet-cell-positive mucosa adjacent to the squamocolumnar junction.
Further workup of intestinalized mucosa
If intestinalized mucosa (Barret's esophagus) is present, look for dysplasia:
Adenocarcinoma Further information: Esophageal adenocarcinoma
Also perform a screening for esophagitis. Further information: Gastroesophageal junction
Incomplete Barret's esophagus does not need specific mention:
Gastroesophageal mucosa with intestinal metaplasia, consistent with Barrett's esophagus.
Negative for dysplasia.
- . Barrett Esophagus. Stanford University School of Medicine. Retrieved on 2020-09-01.
- Dipti M. Karamchandani. Esophagus - Premalignant - Barrett esophagus. Topic Completed: 19 March 2020, Minor changes: 29 June 2020
- Riegler, M.; Kristo, I.; Nikolic, M.; Rieder, E.; Schoppmann, S. F. (2017). "Update on the management of Barrett’s esophagus in Austria
". European Surgery 49 (6): 282–287. doi:10.1007/s10353-017-0504-y. ISSN 1682-8631.
- Fig 2- available via license: Creative Commons Attribution 4.0 International