Barrett's esophagus

Jump to navigation Jump to search

Author: Mikael Häggström [note 1]

Microscopic examination

Generally, the main finding to look for in biopsies from the esophagus is intestinalized mucosa (Barret's esophagus), which is defined as the presence of columnar epithelium with goblet cells.[1] A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered.[2] The mucin usually indents the nucleus.[2]

Further workup of intestinalized mucosa

If intestinalized mucosa (Barret's esophagus) is present, look for dysplasia:

Also perform a screening for esophagitis. Further information: Gastroesophageal junction

Microscopy report

Incomplete Barret's esophagus does not need specific mention:

Histopathology of Barrett's esophagus, annotated.jpg
(GE junction, biopsy:)
Gastroesophageal mucosa with chronic inflammation and intestinal metaplasia, consistent with Barrett's esophagus.
Negative for dysplasia.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. . Barrett Esophagus. Stanford University School of Medicine. Retrieved on 2020-09-01.
  2. 2.0 2.1 Dipti M. Karamchandani. Esophagus - Premalignant - Barrett esophagus. Topic Completed: 19 March 2020, Minor changes: 29 June 2020

Image sources