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- Confirm trilineage hematopoiesis (see image).
- Look for apparent cellular atypia or decrease of cellular diversity.
Example in a normal case:
|Bone marrow from rib (or other location if applicable): Trilineage hematopoiesis. There is no evidence of malignancy.|
Bone marrow biopsy
Evaluate the following:
- Adequacy: There should preferably be 5 intertrabecular spaces.
- Cellularity: In patients 20-80 years, the percentage should be about 100 minus age, such as 40% in a 60 year old patient.
- Thrombopoiesis: There are normally about 3 megakaryocytes per 40x field.
- Myeloid/erythroid ratio, normally 3-4 myeloid cells per erythroid cell.
- Look for any granuloma or cancer metastasis