Endoscopic gastrointestinal biopsies

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Author: Mikael Häggström [note 1]

Endoscopic biopsies   edit
Mostly:

Comprehensiveness

On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Fixation

Generally 10% neutral buffered formalin.

Gross processing

  • Count the number of fragments. They can be classified as “multiple” at over 5 or 6 specimens. Possibly add “Mixed with luminal material”.
  • Preferably stain with eosin if any fragment is smaller than about 0.3 cm
  • Biopsies that are thicker than about 3-4 mm generally need to be bisected.

Microscopic examination

(Read the endoscopy report before evaluating (except for polyp biopsies, where it can be presumed that the purpose is to look for any malignancy).)

Example normal reports

Further information in main articles of each location.

Esophagus
(Middle third esophagus, biopsy:)
Squamous mucosa without significant histopathologic changes.
(Negative for eosinophilic esophagitis.)
Gastroesophageal junction
(GE junction, biopsy:)
Squamous and gastric mucosa without significant histopathologic changes.
(Negative for intestinalized (Barrett's) mucosa.)
Stomach
(Stomach, biopsy:)
Gastric mucosa without significant histopathologic changes.
((Negative for Helicobacter pylori organisms on H&E slide.))
Duodenum
(Small bowel, biopsy:)
Small intestinal mucosa without significant histopathologic changes.
((Negative for celiac disease.))
Terminal ileum
(Small bowel, biopsy:)
Small intestinal mucosa without significant histopathologic changes.
((Negative for ileitis.))
Colon
(Colon, biopsy:)
Colonic mucosa without significant histopathologic changes.
((Negative for colitis.))

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References


Image sources