Granulomatous skin inflammation

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Author: Mikael Häggström [note 1]

Microscopic examination

Granulomatous inflammation is defined by the presence of mononuclear leukocytes, specifically histiocytes, appearing as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells.[1]

Differential diagnosis


  • Look for foreign bodies, conferring a diagnosis of foreign body granuloma.
  • Look for any specific appearance of the giant cells.
  • Look for relation to adnexae or other particular structures.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. Shah, Kabeer K.; Pritt, Bobbi S.; Alexander, Mariam P. (2017). "Histopathologic review of granulomatous inflammation ". Journal of Clinical Tuberculosis and Other Mycobacterial Diseases 7: 1–12. doi:10.1016/j.jctube.2017.02.001. ISSN 24055794. 
  2. Grant-Kels, Jane (2007). Color Atlas of Dermatopathology . City: Informa Healthcare. pp. 107, 119. ISBN 978-0-8493-3794-9. 
  3. Carmen Gómez-Mateo, Maria; Monteagudo, Carlos (2013). "Nonepithelial skin tumors with multinucleated giant cells ". Seminars in Diagnostic Pathology 30 (1): 58–72. doi:10.1053/j.semdp.2012.01.004. PMID 23327730. Archived from the original. . 
  4. Sequeira, Fiona; Gandhi, Suneil (2012). "Named cells in dermatology ". Indian Journal of Dermatology, Venereology and Leprology 78 (2): 207–16. doi:10.4103/0378-6323.93650. PMID 22421663. Archived from the original. . 

Image sources