Molar pregnancy is evidenced by:
- Heterogeneity in villous size with one one hand large, hydropic villi, and small, fibrotic villi on the other.
- Enlarged villi being irregularly shaped with scalloped borders and trophoblastic pseudoinclusions, and sometimes cistern formation
- Trophoblastic hyperplasia
In case of molar pregnancy, perform immunohistochemistry for p57. p57 negative cases with molar morphology are diagnosed as complete hydatidiform moles without genotyping. p57+ cases should be subjected to genotyping.
- Aurelia Busca, Carlos Parra-Herran. Placenta - Gestational trophoblastic disease - Partial hydatidiform mole. PathologyOutlines. Topic Completed: 1 April 2018. Revised: 30 October 2019
- Banet, Natalie; DeScipio, Cheryl; Murphy, Kathleen M; Beierl, Katie; Adams, Emily; Vang, Russell; Ronnett, Brigitte M (2013). "Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping ". Modern Pathology 27 (2): 238–254. doi:10.1038/modpathol.2013.143. ISSN 0893-3952.