Molar pregnancy

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Author: Mikael Häggström [notes 1]

Microscopic evaluation

Molar pregnancy is evidenced by:[1]

  • Heterogeneity in villous size with one one hand large, hydropic villi, and small, fibrotic villi on the other.
  • Enlarged villi being irregularly shaped with scalloped borders and trophoblastic pseudoinclusions, and sometimes cistern formation
  • Trophoblastic hyperplasia

In case of molar pregnancy, perform immunohistochemistry for p57. p57 negative cases with molar morphology are diagnosed as complete hydatidiform moles without genotyping. p57+ cases should be subjected to genotyping.[2]


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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  1. Aurelia Busca, Carlos Parra-Herran. Placenta - Gestational trophoblastic disease - Partial hydatidiform mole. PathologyOutlines. Topic Completed: 1 April 2018. Revised: 30 October 2019
  2. Banet, Natalie; DeScipio, Cheryl; Murphy, Kathleen M; Beierl, Katie; Adams, Emily; Vang, Russell; Ronnett, Brigitte M (2013). "Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping ". Modern Pathology 27 (2): 238–254. doi:10.1038/modpathol.2013.143. ISSN 0893-3952.