Ovarian tumor

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Author: Mikael Häggström [notes 1]

Microscopic evaluation

Ovarian tumors by incidence and risk of ovarian cancer[1]

Look for the most common types of ovarian tumor:

Type Subtype Relative incidence[2] Percent malignant[2] Comments Micrograph
Germ cell tumor Mature cystic teratoma 46% 0.17% to 2%[3] Cystic, with elements of all 3 germ layers (endoderm, mesoderm and ectoderm).[4]
Hair follicles.
Immature teratoma 2.5% 100% A teratoma that contains anaplastic immature elements, and is often synonymous with malignant teratoma.[5] Histopathology of immature teratoma of the ovary.jpg
Other germ cell tumors 3.0% Others mainly include dysgerminoma, yolk sac tumor, struma ovarii and squamous cell carcinoma arising from a dermoid cyst, and malignant mixed germ cell tumor.[2]
Surface epithelial-stromal tumor Serous tumor 25% 18.5% Benign serous tumors of the right ovarian cyst are thinwalled unilocular cysts that are lined by ciliated pseudostratified cuboidal or columnar epithelium.[6] Histopathology of lining of a benign serous tumor of the ovary.jpg
Mucinous tumor 15% 8.8% Benign mucinous tumors of the ovary consist of simple, nonstratified columnar epithelium with basally-located hyperchromatic nuclei and resemble gastric foveolar epithelium.[6] Histopathology of lining of a benign mucinous tumor of the ovary.jpg
Endometrioid tumor 1% Almost 100% Tubular glands, resembling endometrium.[7] Histopathology of well-differentiated endometrioid adenocarcinoma.png
Other surface-epithelial tumors 1.5% Others include mainly malignant mixed mullerian tumor, Brenner tumor and mixed epithelial tumor.[2]
Sex cord-stromal tumor Ovarian fibroma 1.5% 0% Spindle-shaped fibroblastic cells and abundant collagen.[8] Histopathology of an ovarian fibroma.jpg
Adult granulosa cell tumor 1% Almost 100% Small, bland, cuboidal to polygonal cells in various patterns.[9] Granulosa Cell Tumor of the Ovary (5621714007).jpg
Other sex cord-stromal tumors 1% Others include mainly juvenile granulosa cell tumor, thecoma and sclerosing stromal tumor[2]
Secondary/metastatic) tumor 2% 100% Usually from breast cancer, colon cancer, endometrial cancer, stomach cancer or cervical cancer.[10]

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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References

  1. - Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal ". Journal of Pathology of Nepal 4 (7): 539–543. doi:10.3126/jpn.v4i7.10295. ISSN 2091-0908. 
    - Minor adjustment for mature cystic teratomas (0.17 to 2% risk of ovarian cancer): Mandal, Shramana; Badhe, Bhawana A. (2012). "Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report ". Case Reports in Pathology 2012: 1–3. doi:10.1155/2012/568062. ISSN 2090-6781. 
  2. 2.0 2.1 2.2 2.3 2.4 Unless otherwise specified in boxes, reference is: Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal ". Journal of Pathology of Nepal 4 (7): 539–543. doi:10.3126/jpn.v4i7.10295. ISSN 2091-0908. 
  3. Mandal, Shramana; Badhe, Bhawana A. (2012). "Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report ". Case Reports in Pathology 2012: 1–3. doi:10.1155/2012/568062. ISSN 2090-6781. 
  4. Hillary Rose Elwood. Skin nonmelanocytic tumor - Other tumors of skin - Benign (mature) cystic teratoma. pathology Outlines. Topic Completed: 1 November 2016. Revised: 4 April 2019
  5. Sun, Hang; Ding, Hongxin; Wang, Jianjun; Zhang, Emma; Fang, Yihua; Li, Zhenhua; Yu, Xiao; Wang, Chongren; et al. (2019). "The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy ". BMC Cancer 19 (1). doi:10.1186/s12885-019-5598-0. ISSN 1471-2407. 
  6. 6.0 6.1 Baradwan, Saeed; Alalyani, Haneen; Baradwan, Amira; Baradwan, Afnan; Al-Ghamdi, Maram; Alnemari, Jameel; Al-Jaroudi, Dania (2018). "Bilateral ovarian masses with different histopathology in each ovary ". Clinical Case Reports 6 (5): 784–787. doi:10.1002/ccr3.1466. ISSN 20500904. 
  7. Shahrzad Ehdaivand. Ovary tumor - Endometrioid tumors - General. Pathology Outlines. Topic Completed: 1 December 2012. Revised: 6 March 2020
  8. Parwate, Nikhil Sadanand; Patel, Shilpa M.; Arora, Ruchi; Gupta, Monisha (2015). "Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature ". The Journal of Obstetrics and Gynecology of India 66 (6): 460–465. doi:10.1007/s13224-015-0717-6. ISSN 0971-9202. 
  9. Shahrzad Ehdaivand. Ovary tumor - Sex cord stromal tumors - Granulosa cell tumor - adult. Pathology Outlines. Topic Completed: 1 December 2012. Revised: 9 March 2020
  10. Lisa Lee-Jones, University of Wales College of Medicine (2003-12-01). Ovarian tumours : an overview. Atlas of Genetics and Cytogenetics in Oncology and Haematology.