Platelet aggregation study

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Author: Mikael Häggström [note 1]

On for example optical densitometry, a first and second wave of platelet aggregation is seen, in this case for an ADP-initiated aggregation.[1]

In a platelet aggregation study, the aggregation process is started by different agonists (ADP, epinephrine etc.) and the aggregation pattern can usually conform into any of the following patterns:

Platelet aggregation function by disorders and agonists
ADP Epinephrine Collagen Ristocetin
P2Y receptor defect[2] (including Clopidogrel) Decreased Normal Normal Normal
Adrenergic receptor defect[2] Normal Decreased Normal Normal
Collagen receptor defect[2] Normal Normal Decreased or absent Normal
  • Von Willebrand disease[3]
  • Bernard–Soulier syndrome[2]
Normal Normal Normal Decreased or absent
  • Glanzmann's thrombasthenia[2]
  • Afibrinogenemia
Decreased Decreased Decreased Normal or decreased
Storage pool deficiency[3] Absent second wave Partial
Aspirin or aspirin-like disorder Absent second wave Absent Normal

Further reading


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. Jiang, L.; Xu, C.; Yu, S.; Liu, P.; Luo, D.; Zhou, Q.; Gao, C.; Hu, H. (2013). "A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation ". Journal of Thrombosis and Haemostasis 11 (5): 930–940. doi:10.1111/jth.12168. ISSN 15387933. PMID 23406164. 
  2. 2.0 2.1 2.2 2.3 2.4 Borhany, Munira; Pahore, Zaen; ul Qadr, Zeeshan; Rehan, Muhammad; Naz, Arshi; Khan, Asif; Ansari, Saqib; Farzana, Tasneem; et al. (2010). "Bleeding disorders in the tribe: result of consanguineous in breeding ". Orphanet Journal of Rare Diseases 5 (1). doi:10.1186/1750-1172-5-23. ISSN 1750-1172. 
  3. 3.0 3.1 . Why Perform Platelet Aggregation?. Helena Biosciences. 2015

Image sources