Small intestine in celiac disease
As per Small intestine.
The main histologic feature of celiac disease is increased intraepithelial lymphocytes (IELs), with or without villous atrophy of the duodenal mucosa. The number of intraepithelial lymphocytes are classified as follows in the duodenum:
- < 25 IELs/100 enterocytes: Negative for intraepithelial lymphocytosis.
- 25 to 29 IELs/100 enterocytes: borderline
- > 30 IEL/100 enterocytes: Pathological "lymphocytosis"
Suggestive but not specific findings for enterocytes are: decreased height, intracytoplasmic vacuolation and reduction or absence of the brush border.
If findings are suggestive of celiac disease, look for at least the following differential diagnoses:
Giardia lamblia: Organisms shaped like teardropd or pears, with paired nuclei, seen in the lumen between villi.
Example in an unremarkable specimen:
|Duodenal mucosa, negative for significant histopathologic changes.|
Negative for celiac disease.
- Brown, Ian S.; Smith, Jason; Rosty, Christophe (2012). "Gastrointestinal Pathology in Celiac Disease ". American Journal of Clinical Pathology 138 (1): 42–49. doi:10.1309/AJCPE89ZPVJTSPWL. ISSN 0002-9173.
- Erdener Özer. Small intestine & ampulla, Malabsorption, Celiac sprue. Pathology Outlines. Topic Completed: 1 June 2017. Minor changes: 4 April 2020.
- . Celiac Disease. Stanford School of Medicine. Retrieved on 2021-03-11.
- Hanni Gulwani. Small intestine & ampulla - Infectious disorders - Giardia lamblia. Pathology Outlines. Topic Completed: 1 August 2012. Minor changes: 3 March 2020