Spindle-cell tumors of the midgut

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Author: Mikael Häggström [note 1]

Leiomyoma of the ileocecal valve.


Microscopic evaluation

Generally perform c-Kit immunohistochemistry to detect any gastrointestinal stromal tumor (GIST),[1] and optionally addition of CD34 (both typically being positive in GIST). In contrast, leiomyomas can be confirmed with positive staining for actin, and optionally addition of desmin (with leiomyomas typically being positive for these and negative for c-Kit and CD34).


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. Lee, So Jung; Hwang, Chung Su; Kim, Ahrong; Kim, Kyungbin; Choi, Kyung Un (2016). "Gastrointestinal tract spindle cell tumors with interstitial cells of Cajal: Prevalence excluding gastrointestinal stromal tumors ". Oncology Letters 12 (2): 1287–1292. doi:10.3892/ol.2016.4758. ISSN 1792-1074. 

Image sources