Mikael Häggström [note 1]
Thyroid hyperplasia as a histopathological diagnosis corresponds mainly to the clinical diagnoses of toxic multinodular goiter and Grave's disease (the latter usually shows more prominent hyperplasia).
Further information: Thyroid
Diffuse thyroid hyperplasia typically shows variably sized follicles.
Thyroid hyperplasia with a hyperplastic nodule. It characteristically has no capsule (distinguishing it from thyroid adenoma or carcinoma).
The epithelium may also be flattened by enlarged follicles.
As shown, it can have mildly enlarged nuclei with mildly clumped chromatin, and clear cytoplasms, but cellular characteristics of papillary thyroid carcinoma are absent.
Thyroid hyperplasia with a Sanderson polster, which is a group of small follicles that protrude into the lumen of a larger follicle. It should not be confused for papillary projections.
Various forms of degeneration are typically seen, with various forms pictured.
|Right and left thyroid lobe, total thyroidectomy:
- Multinodular hyperplasia with focal chronic inflammation.
- Negative for malignancy.
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