Thyroid hyperplasia
Author:
Mikael Häggström [note 1]
Thyroid hyperplasia as a histopathological diagnosis corresponds mainly to the clinical diagnoses of toxic multinodular goiter and Grave's disease (the latter usually shows more prominent hyperplasia).
Contents
Gross processing
Further information: Thyroid
Microscopic evaluation
Diffuse thyroid hyperplasia typically shows variably sized follicles.
Thyroid hyperplasia with a hyperplastic nodule. It characteristically has no capsule (distinguishing it from thyroid adenoma or carcinoma).
The follicular linings may be thickened, with papillary projections (but lack nuclear features of papillary thyroid carcinoma).
The epithelium may also be flattened by enlarged follicles.
It can show hypercellular or microfollicular areas. There is no surrounding capsule (in contrast, a thyroid follicular adenoma or thyroid follicular carcinoma is generally encapsulated).
As shown, it can have mildly enlarged nuclei with mildly clumped chromatin, and clear cytoplasms, but cellular characteristics of papillary thyroid carcinoma are absent.
Thyroid hyperplasia with a Sanderson polster, which is a group of small follicles that protrude into the lumen of a larger follicle. It should not be confused for papillary projections.
Various forms of degeneration are typically seen, with various forms pictured.
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Reporting
Example:
Right and left thyroid lobe, total thyroidectomy:
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Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
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