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Author: Mikael Häggström [note 1]

Lymphoid follicle with a central germinal center surrounded by lymphocytes, which is a finding that can be seen in both focal lymphocytic thyroiditis and Hashimoto's disease.[1]

Thyroiditis is defined by a significant inflammatory infiltrate. When seen, check the patients medical records for known diagnoses or other obvious clues. Attempt to classify into one of the main types:[1]

Type Lymph follicles Giant cells
Focal lymphocytic thyroiditis Usually No
Hashimoto thyroiditis Usually Relatively small and sparse
De Quervain's thyroiditis No Relatively large and numerous

However, if no clear distinction can be made, and especially if the thyroiditis is not the primary reason for the biopsy or excision, it is acceptable to state "chronic thyroiditis, non-specific" without additional workup.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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  1. 1.0 1.1 Knecht H, Saremaslani P, Hedinger C (1981). "Immunohistological findings in Hashimoto's thyroiditis, focal lymphocytic thyroiditis and thyroiditis de Quervain. Comparative study. ". Virchows Arch A Pathol Anat Histol 393 (2): 215-31. doi:10.1007/BF00431078. PMID 6895270. Archived from the original. . 

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