Traditional serrated adenoma

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Author: Mikael Häggström [note 1]

Traditional Serrated Adenoma of Colon (5203904731).jpg


Microscopic evaluation

This case lacks the typical eosinophilic cytoplasm, but otherwise typical with protuberant villiform growth pattern with slit-like serrations and presence of goblet cells.
  • Protuberant villi with slit-like serrations.[1]
  • Pseudostratified epithelial columnar cells shapes.[1]
  • Eosinophilic cytoplasm and dark, pencil-like nuclei.[1]
  • Golblet cells are present.[1]

Differential diagnosis


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. 1.0 1.1 1.2 1.3 Enoch Kuo, M.D., Raul S. Gonzalez, M.D.. Colon - Polyps - Traditional serrated adenoma. Topic Completed: 1 February 2018. Minor changes: 1 October 2020
  2. Torlakovic, Emina Emilia; Gomez, Jose D.; Driman, David K.; Parfitt, Jeremy R.; Wang, Chang; Benerjee, Tama; Snover, Dale C. (2008). "Sessile Serrated Adenoma (SSA) vs. Traditional Serrated Adenoma (TSA) ". The American Journal of Surgical Pathology 32 (1): 21–29. doi:10.1097/PAS.0b013e318157f002. ISSN 0147-5185. 

Image sources