Granulomatous skin inflammation: Difference between revisions
Jump to navigation
Jump to search
+rupture |
Expanded |
||
| Line 4: | Line 4: | ||
}} | }} | ||
==Microscopic examination== | |||
Granulomatous inflammation is defined by the presence of mononuclear leukocytes, specifically histiocytes, appearing as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells.<ref name="ShahPritt2017">{{cite journal|last1=Shah|first1=Kabeer K.|last2=Pritt|first2=Bobbi S.|last3=Alexander|first3=Mariam P.|title=Histopathologic review of granulomatous inflammation|journal=Journal of Clinical Tuberculosis and Other Mycobacterial Diseases|volume=7|year=2017|pages=1–12|issn=24055794|doi=10.1016/j.jctube.2017.02.001}}</ref> | |||
===Differential diagnosis=== | |||
*Other forms of '''[[dermatitis]]''' if other types of inflammatory cells are prevalent. | |||
*'''[[Suspected malignant skin excisions|Suspected malignant skin lesions]]''' if demonstrating cellular atypia | |||
===Workup=== | |||
*Look for '''foreign bodies''', conferring a diagnosis of ''foreign body granuloma''. | *Look for '''foreign bodies''', conferring a diagnosis of ''foreign body granuloma''. | ||
*Look for any specific '''appearance''' of the giant cells. | *Look for any specific '''appearance''' of the giant cells. | ||
| Line 13: | Line 21: | ||
File:Histopathology of granulomatous inflammation by a ruptured inclusion cyst.jpg|Granulomatious inflammation following an epidermal inclusion '''cyst rupture''', with giant cells surrounding keratin flakes. | File:Histopathology of granulomatous inflammation by a ruptured inclusion cyst.jpg|Granulomatious inflammation following an epidermal inclusion '''cyst rupture''', with giant cells surrounding keratin flakes. | ||
</gallery> | </gallery> | ||
{{Bottom}} | {{Bottom}} | ||