Peripheral blood smear: Difference between revisions

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White blood cells: +Atypical lymphs
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;Burr cells versus spur cells
;Burr cells versus spur cells
<gallery mode=packed heights=150>
<gallery mode="packed" heights="150">
File:Micrograph of an echinocyte on a peripheral blood smear.jpg|'''Burr cell''' (echinocyte)
File:Micrograph of an echinocyte on a peripheral blood smear.jpg|'''Burr cell''' (echinocyte)
File:Human blood film with acanthocytes 02.jpg|'''Spur cell''' (acanthocyte)
File:Human blood film with acanthocytes 02.jpg|'''Spur cell''' (acanthocyte)
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;Intraerythrocytic findings
;Intraerythrocytic findings
<gallery mode=packed heights=150>
<gallery mode="packed" heights="150">
File:Micrograph of a red blood cells with an overlying platelet on a peripheral blood smear.jpg|When seeing what appears to a platelet overlying a red blood cells (as pictured), confirm that there is a halo.
File:Micrograph of a red blood cells with an overlying platelet on a peripheral blood smear.jpg|When seeing what appears to a platelet overlying a red blood cells (as pictured), confirm that there is a halo.
File:Human blood film with babesia.jpg|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).
File:Human blood film with babesia.jpg|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).
</gallery>
</gallery>
<gallery mode=packed heights=250>
<gallery mode="packed" heights="250">
File:Blood stages of P. falciparum over 48h.jpg|'''Malaria''', showing appearance at different intraerythrocytic blood stages.
File:Blood stages of P. falciparum over 48h.jpg|'''Malaria''', showing appearance at different intraerythrocytic blood stages.
File:Thick blood film with Plasmodium falciparum rings and schizonts.png|If '''malaria''' is suspected, also make a thick blood film.
File:Thick blood film with Plasmodium falciparum rings and schizonts.png|If '''malaria''' is suspected, also make a thick blood film.
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[[File:Monoblast, promonocyte and monocyte.jpg|thumb|400px|Comparison of monoblast, promonocyte and monocyte. {{further|Suspected blasts on peripheral blood smear}}]]
[[File:Monoblast, promonocyte and monocyte.jpg|thumb|400px|Comparison of monoblast, promonocyte and monocyte. {{further|Suspected blasts on peripheral blood smear}}]]
A common practice is to evaluate at least 100 white blood cells. Look for:
A common practice is to evaluate at least 100 white blood cells. Look for:
<gallery mode=packed heights=190>
<gallery mode="packed" heights="190">
File:Myeloblast with Auer rod.jpg|thumb|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further|Suspected blasts on peripheral blood smear}}
File:Myeloblast with Auer rod.jpg|thumb|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further|Suspected blasts on peripheral blood smear}}
File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref>
File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref>
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{| class="wikitable" style="text-align:center; vertical-align:middle;"
{| class="wikitable" style="text-align:center; vertical-align:middle;"
|+ Atypical lymphocytes:<ref name="Nozaka2023">{{cite journal
|+ Atypical/Reactive lymphocytes:<ref name="Nozaka2023">{{cite journal
  |last1=Nozaka |first1=Hiroyuki
  |last1=Nozaka |first1=Hiroyuki
  |last2=Kushibiki |first2=Mihoko
  |last2=Kushibiki |first2=Mihoko
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! Type II<br />(plasma cell-like) - Most common
! Type II<br />(plasma cell-like) - Most common
! Type III<br />(lymphoblast-like)
! Type III<br />(lymphoblast-like)
|-
! Typical morphology
| [[File:Type 1 atypical lymphocyte.png|180px|center|Type I (monocyte-like) atypical lymphocyte]]
| [[File:Type 2 atypical lymphocyte.png|180px|center|Type II (plasma cell-like) atypical lymphocyte]]
| [[File:Type 3 atypical lymphocyte.png|180px|center|Type III (lymphoblast-like) atypical lymphocyte]]
|-
|-
! Size
! Size
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| Azurophilic granules (±)
| Azurophilic granules (±)
| —
| —
|-
! Typical morphology
| [[File:Type 1 atypical lymphocyte.png|180px|center|Type I (monocyte-like) atypical lymphocyte]]
| [[File:Type 2 atypical lymphocyte.png|180px|center|Type II (plasma cell-like) atypical lymphocyte]]
| [[File:Type 3 atypical lymphocyte.png|180px|center|Type III (lymphoblast-like) atypical lymphocyte]]
|}
|}