Lipomatous tumor: Difference between revisions
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==Microscopic evaluation== | ==Microscopic evaluation== | ||
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File:Histopathology of lipoma.jpg|'''Lipoma''': lobules of mature white adipose tissue divided by delicate and inconspicuous fibrous septa containing thin-walled capillary-sized vessels. | File:Histopathology of lipoma.jpg|'''Lipoma''': lobules of mature white adipose tissue divided by delicate and inconspicuous fibrous septa containing thin-walled capillary-sized vessels. Still, look close at the fibrous septa: | ||
File:Histopathology of an atypical lipomatous tumor or well-differentiated liposarcoma, lipoma-like subtype.jpg|An '''atypical lipomatous tumor''' (also termed '''well-differentiated liposarcoma'''), lipoma-like subtype. At low magnification, the majority of the tumor has the look of benign mature adipocytes, but a high magnification of a fibrous band shows spindle cells with enlarged, hyperchromatic nuclei. | |||
File:Histopathology of a fibrolipoma.jpg|'''Fibrolipoma''' is a lipoma with focal areas of large amounts of fibrous tissue.<br>A '''sclerotic lipoma''' is one step further: a predominantly fibrous lesion with focal areas of fat.<ref>{{cite web|url=http://surgpathcriteria.stanford.edu/softfat/lipoma/fibrolipoma.html|title=Lipoma Variant: Fibrolipoma|website=Stanford University School of Medicine|accessdate=2020-02-10}}</ref><br>If unsure of degree of fibrosis: Simply report as lipoma. | File:Histopathology of a fibrolipoma.jpg|'''Fibrolipoma''' is a lipoma with focal areas of large amounts of fibrous tissue.<br>A '''sclerotic lipoma''' is one step further: a predominantly fibrous lesion with focal areas of fat.<ref>{{cite web|url=http://surgpathcriteria.stanford.edu/softfat/lipoma/fibrolipoma.html|title=Lipoma Variant: Fibrolipoma|website=Stanford University School of Medicine|accessdate=2020-02-10}}</ref><br>If unsure of degree of fibrosis: Simply report as lipoma. | ||
File:Histopathology of angiolipoma.jpg|'''Angiolipoma''' is a lipoma with abundant capillaries, with hyaline or fibrin (pictured) thrombi.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/softtissueadiposeangiolipoma.html|title=Soft tissue - Adipose tissue tumors - Lipoma and variants - Angiolipoma|author=Vijay Shankar|website=Pathology Outlines}} Topic Completed: 1 August 2012. Minor changes: 20 March 2019</ref> | File:Histopathology of angiolipoma.jpg|'''Angiolipoma''' is a lipoma with abundant capillaries, with hyaline or fibrin (pictured) thrombi.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/softtissueadiposeangiolipoma.html|title=Soft tissue - Adipose tissue tumors - Lipoma and variants - Angiolipoma|author=Vijay Shankar|website=Pathology Outlines}} Topic Completed: 1 August 2012. Minor changes: 20 March 2019</ref> | ||
File:Histopathology of liposarcoma, annotated.jpg|Main features of '''liposarcoma''':<ref name=PathologyOutlines>{{cite web|url=https://www.pathologyoutlines.com/topic/softtissuewdliposarcoma.html%7Ctitle=Liposarcoma|author=Michael R. Clay, M.D.|website=PathologyOutlines|title=Liposarcoma}} Topic Completed: 1 November 2017. Minor changes: 11 May 2021</ref><br>- Spindle cells with enlarged, hyperchromatic nuclei.<br>- Apparently univacuolated adipocytes (may look normal).<br>- [[Lipoblast]]s (multivacuolated), but neither necessary nor sufficient for diagnosis. | File:Histopathology of liposarcoma, annotated.jpg|Main features of '''liposarcoma''':<ref name=PathologyOutlines>{{cite web|url=https://www.pathologyoutlines.com/topic/softtissuewdliposarcoma.html%7Ctitle=Liposarcoma|author=Michael R. Clay, M.D.|website=PathologyOutlines|title=Liposarcoma}} Topic Completed: 1 November 2017. Minor changes: 11 May 2021</ref><br>- Spindle cells with enlarged, hyperchromatic nuclei.<br>- Apparently univacuolated adipocytes (may look normal).<br>- [[Lipoblast]]s (multivacuolated), but neither necessary nor sufficient for diagnosis. | ||
File:Myxoid liposarcoma (16105753363).jpg|'''Myxoid liposarcoma''': Hypercellular solid sheets of cells lying back to back, with round cells or primitive cytomorphology.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/softtissuemyxoidliposarcoma.html|title=Soft tissue - Adipose tissue - Myxoid liposarcoma|author=Michael R. Clay|website=PathologyOutlines}} Topic Completed: 1 January 2018. Revised: 20 March 2019</ref> | File:Myxoid liposarcoma (16105753363).jpg|'''Myxoid liposarcoma''': Hypercellular solid sheets of cells lying back to back, with round cells or primitive cytomorphology.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/softtissuemyxoidliposarcoma.html|title=Soft tissue - Adipose tissue - Myxoid liposarcoma|author=Michael R. Clay|website=PathologyOutlines}} Topic Completed: 1 January 2018. Revised: 20 March 2019</ref> | ||