Peripheral blood smear: Difference between revisions
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Look at and comment separately on white blood cells, red blood cells and platelets. You generally don't need to aim for a perfect report, because for most purposes, a peripheral smear is a relatively simple screening test, and clinicians may opt to perform for example flow cytometry and/or a bone marrow biopsy if they want a better evaluation. | |||
Look at and comment separately on white blood cells, red blood cells and platelets. | |||
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==Oil immersion microscopy== | ==Oil immersion microscopy== | ||
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File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref> | File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref> | ||
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When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web|url=http://www.captodayonline.com/Archives/0610/0610_qa.html|website=CAP Today|author=Fredrick L. Kiechle}} June 2010</ref> | When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web|url=http://www.captodayonline.com/Archives/0610/0610_qa.html|website=CAP Today|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin. | ||
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