Peripheral blood smear: Difference between revisions
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File:Myeloblast with Auer rod.jpg|thumb|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). | File:Myeloblast with Auer rod.jpg|thumb|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). | ||
File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref> | File:Hypersegmented neutrophil.jpg|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book | last=Glassy | first=Eric | title=Color atlas of hematology : an illustrated field guide based on proficiency testing | publisher=College of American Patholgists | publication-place=Northfield, Ill | year=1998 | isbn=978-0-930304-66-9 | oclc=40976106 | page=}}</ref> | ||
File:Prolymphocyte in peripheral blood smear.png|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload|title=prolymphocytes in PLL|website=American Society of Hematology|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such. | |||
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When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web|url=http://www.captodayonline.com/Archives/0610/0610_qa.html|website=CAP Today|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin. | When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web|url=http://www.captodayonline.com/Archives/0610/0610_qa.html|website=CAP Today|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin. | ||