Ductal carcinoma in situ: Difference between revisions

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File:Histopathology of microinvasive ductal carcinoma in situ.png|'''DCIS with microinvasion''', defined as DCIS with focus of invasive cancer measuring up to 1.0 mm in size.<ref>Image annotation by Mikael Häggström, MD, using source image from:<br>{{cite journal| author=Moatasim A, Mamoon N| title=Primary Breast Mucinous Cystadenocarcinoma and Review of Literature. | journal=Cureus | year= 2022 | volume= 14 | issue= 3 | pages= e23098 | pmid=35464581 | doi=10.7759/cureus.23098 | pmc=8997314 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35464581  }}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0."<br>'''Source for microinvasion''': {{cite web|url=https://documents.cap.org/protocols/Breast.DCIS_4.4.0.0.REL_CAPCP.pdf|title=Protocol for the Examination of Resection Specimens from Patients with Ductal Carcinoma In Situ (DCIS) of the Breast, Version: 4.4.0.0. Protocol Posting Date: June 2021|website=College of American Pathologists}}</ref>
File:Histopathology of microinvasive ductal carcinoma in situ.png|'''DCIS with microinvasion''', defined as DCIS with focus of invasive cancer measuring up to 1.0 mm in size.<ref>Image annotation by Mikael Häggström, MD, using source image from:<br>{{cite journal| author=Moatasim A, Mamoon N| title=Primary Breast Mucinous Cystadenocarcinoma and Review of Literature. | journal=Cureus | year= 2022 | volume= 14 | issue= 3 | pages= e23098 | pmid=35464581 | doi=10.7759/cureus.23098 | pmc=8997314 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35464581  }}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0."<br>'''Source for microinvasion''': {{cite web|url=https://documents.cap.org/protocols/Breast.DCIS_4.4.0.0.REL_CAPCP.pdf|title=Protocol for the Examination of Resection Specimens from Patients with Ductal Carcinoma In Situ (DCIS) of the Breast, Version: 4.4.0.0. Protocol Posting Date: June 2021|website=College of American Pathologists}}</ref>
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In uncertain cases, use immunohistochemistry stain for '''calponin''' (has the highest sensitivity) and '''p63''' (has the highest specificity).
In uncertain cases, use immunohistochemistry stain for myoepithelial markers{{Myoepithelial marker note}}.
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File:Immunohistochemistry with calponin in ductal carcinoma in situ.jpg|Immunohistochemistry for the myoepithelial marker{{Myoepithelial marker note}} calponin in '''ductal carcinoma in situ''', highlighting myoepithelial cells around all tumor cells, thereby ruling out [[invasive ductal carcinoma]].
File:Immunohistochemistry with calponin in ductal carcinoma in situ.jpg|Immunohistochemistry for the myoepithelial marker{{Myoepithelial marker note}} calponin in '''ductal carcinoma in situ''', highlighting myoepithelial cells around all tumor cells, thereby ruling out [[invasive ductal carcinoma]].
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