Cirrhosis: Difference between revisions

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m Gross processing: in autopsy
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Cirrhosis of the [[liver]]:
Cirrhosis of the [[liver]]:


==Gross processing==
==Gross processing in autopsy==
{{Gross processing of the liver}}
{{Gross processing of the liver}}



Revision as of 02:59, 20 December 2019

Author: Mikael Häggström [note 1]
Cirrhosis of the liver:

Gross processing in autopsy

Template:Gross processing of the liver

Gross examination

Cirrhosis is characterized by pale areas. Categorize into either of the following: (1) micronodular, (2) macronodular, or (3) mixed:[1]

File:Gross pathology of alcoholic liver cirrhosis.jpg
Micronodular cirrhosis, with diffuse areas of pallor.
  • Micronodular or diffuse cirrhosis (uniform nodules less than 3 mm in diameter).[notes 1]
  • Macronodular cirrhosis (irregular nodules with a variation greater than 3 mm in diameter): Cirrhosis due to hepatitis B and C, alpha-1 antitrypsin deficiency, and primary biliary cholangitis.
  • Mixed cirrhosis (when features of both micronodular and macronodular cirrhosis are present): Usually micronodular cirrhosis progresses into macronodular cirrhosis over time.

Microscopic evaluation

File:Cirrhosis of the liver (trichrome stain) (5690946257).jpg
Trichrome stain, showing cirrhosis as a nodular texture surrounded by fibrosis (wherein collagen is stained blue).

Components:[1]

  • Diagnosing cirrhosis. The diagnosis of cirrhosis by biopsy requires the presence of fibrosis and nodules.
  • Assessing the degree of inflammation (grade) and fibrosis (stage) of the disease.

Notes

  1. Micronodular or diffuse cirrhosis can be due to alcohol, hemochromatosis, hepatic venous outflow obstruction, chronic biliary obstruction, jejunoileal bypass, and Indian childhood cirrhosis.
  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Bashar Sharma; Savio John.. Hepatic Cirrhosis. StatPearls at the National Center for Biotechnology Information. Last Update: June 3, 2019.

Image sources