Cirrhosis: Difference between revisions

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==Microscopic evaluation==
==Microscopic evaluation==
[[File:Cirrhosis of the liver (trichrome stain) (5690946257).jpg|thumb|[[Trichrome stain]], showing cirrhosis as a nodular texture surrounded by fibrosis (wherein collagen is stained blue).]]
Components:<ref name=ncbi/>
Components:<ref name=ncbi/>
*'''Diagnosing''' cirrhosis. The diagnosis of cirrhosis by biopsy requires the presence of fibrosis and nodules.
*'''Diagnosing''' cirrhosis. The diagnosis of cirrhosis by biopsy requires the presence of fibrosis and nodules.
*Assessing the degree of '''inflammation''' (grade) and '''fibrosis''' (stage) of the disease.  
*Assessing the degree of '''inflammation''' (grade) and '''fibrosis''' (stage) of the disease.  


<gallery mode=packed heights=180>
File:Histopathology of mild zone 3 steatosis without fibrosis (van Gieson).jpg|'''No fibrosis''', but mild zone 3 steatosis (van Gieson's stain)<ref name="BoydCain2020"/>
File:Histopathology of steatohepatitis with mild fibrosis in the form of fibrous expansion (van Gieson).jpg|Histopathology of steatohepatitis with '''mild fibrosis''' in the form of fibrous expansion (van Gieson's stain)<ref name="BoydCain2020"/>
File:Histopathology of steatohepatitis with moderate fibrosis, with thin fibrous bridges (van Gieson).jpg|Histopathology of steatohepatitis with '''moderate fibrosis''', with thin fibrous bridges (van Gieson's stain)<ref name="BoydCain2020"/>
File:Histopathology of steatohepatitis with established cirrhosis, with thick bands of fibrosis (van Gieson).jpg|Histopathology of steatohepatitis with '''established cirrhosis''', with thick bands of fibrosis (van Gieson's stain)<ref name="BoydCain2020"/>
File:Cirrhosis of the liver (trichrome stain) (5690946257).jpg|[[Trichrome stain]], showing cirrhosis as a nodular texture surrounded by fibrosis (wherein collagen is stained blue).
</gallery>
{{Bottom}}
{{Bottom}}

Revision as of 06:33, 20 December 2019

Author: Mikael Häggström [note 1]
Cirrhosis of the liver:

Gross processing

In autopsy, make consecutive liver slices, such as in the sagittal or coronal plane.

Gross examination

Cirrhosis is characterized by pale areas. Categorize into either of the following: (1) micronodular, (2) macronodular, or (3) mixed:[1]

File:Gross pathology of alcoholic liver cirrhosis.jpg
Micronodular cirrhosis, with diffuse areas of pallor.
  • Micronodular or diffuse cirrhosis (uniform nodules less than 3 mm in diameter).[notes 1]
  • Macronodular cirrhosis (irregular nodules with a variation greater than 3 mm in diameter).
  • Mixed cirrhosis (when features of both micronodular and macronodular cirrhosis are present): Usually micronodular cirrhosis progresses into macronodular cirrhosis over time.

Microscopic evaluation

Components:[1]

  • Diagnosing cirrhosis. The diagnosis of cirrhosis by biopsy requires the presence of fibrosis and nodules.
  • Assessing the degree of inflammation (grade) and fibrosis (stage) of the disease.

Notes

  1. ↑ Micronodular or diffuse cirrhosis can be due to alcohol, hemochromatosis, hepatic venous outflow obstruction, chronic biliary obstruction, jejunoileal bypass, and Indian childhood cirrhosis.
  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ 1.0 1.1 Bashar Sharma; Savio John.. Hepatic Cirrhosis. StatPearls at the National Center for Biotechnology Information. Last Update: June 3, 2019.
  2. ↑ 2.0 2.1 2.2 2.3 Cite error: Invalid <ref> tag; no text was provided for refs named BoydCain2020

Image sources


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