Granulomatous skin inflammation

Look for foreign bodies, conferring a diagnosis of foreign body granuloma.
Look for any specific appearance of the giant cells.
Look for relation to adnexae or other particular structures.

Foreign body: Suture granuloma, with multinucleated giant cells surrounding (grey) suture material.

Foreign body: Suture granuloma, with multinucleated giant cells surrounding (grey) suture material.
Appearance: A Touton giant cell contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.[1][2] The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.[3]

Appearance: A Touton giant cell contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.^[1]^[2] The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.^[3]
Relation: Folliculitis with multinucleated giant cells surrounding a hair follicle.

Relation: Folliculitis with multinucleated giant cells surrounding a hair follicle.
Granulomatious inflammation following an epidermal inclusion cyst rupture, with giant cells surrounding keratin flakes.

Granulomatious inflammation following an epidermal inclusion cyst rupture, with giant cells surrounding keratin flakes.

Notes

↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

↑ Grant-Kels, Jane (2007). Color Atlas of Dermatopathology . City: Informa Healthcare. pp. 107, 119. ISBN 978-0-8493-3794-9.
↑ Carmen Gómez-Mateo, Maria; Monteagudo, Carlos (2013). "Nonepithelial skin tumors with multinucleated giant cells ". Seminars in Diagnostic Pathology 30 (1): 58–72. doi:10.1053/j.semdp.2012.01.004. PMID 23327730. Archived from the original. .
↑ Sequeira, Fiona; Gandhi, Suneil (2012). "Named cells in dermatology ". Indian Journal of Dermatology, Venereology and Leprology 78 (2): 207–16. doi:10.4103/0378-6323.93650. PMID 22421663. Archived from the original. .