Atypical ductal hyperplasia
Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.
There is no single definite cutoff that separates atypical ductal hyperplasia from ductal carcinoma in situ, but the following are important distinctive features of atypical ductal hyperplasia, with suggested cutoffs:
- Size less than 2 mm.
- Not involving more than one duct.
- The atypical epithelial proliferation is admixed with a second population of proliferative cells without atypia.
- The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.
Also, ADH tends to have rounded lacunae between cells, in contrast to more crescent-shaped (compressed) lucunae in DCIS.
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