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In case of myocardial fibrosis, attempt to distinguish between the following:
- Interstitial fibrosis, which is unspecific, (and may simply reported as such).[notes 1]
- Subepicardial fibrosis, also unspecific (and may simply be reported as such).[notes 2]
- Replacement fibrosis, which indicates an older infarction.
Example (if uncertain whether there is replacement fibrosis or merely subepicardial fibrosis):
- Interstitial fibrosis has been described in congestive heart failure, hypertension, and normal aging. (Chute, 2019)
- Subepicardial fibrosis is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy.
- Gräni, Christoph; Eichhorn, Christian; Bière, Loïc; Kaneko, Kyoichi; Murthy, Venkatesh L.; Agarwal, Vikram; Aghayev, Ayaz; Steigner, Michael; et al. (2019). "Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis ". Journal of Cardiovascular Magnetic Resonance 21 (1). doi:10.1186/s12968-019-0520-0. ISSN 1532-429X.
- Bhaskaran, Ashwin; Tung, Roderick; Stevenson, William G.; Kumar, Saurabh (2019). "Catheter Ablation of VT in Non-Ischaemic Cardiomyopathies: Endocardial, Epicardial and Intramural Approaches ". Heart, Lung and Circulation 28 (1): 84–101. doi:10.1016/j.hlc.2018.10.007. ISSN 14439506.
- Chute, Michael; Aujla, Preetinder; Jana, Sayantan; Kassiri, Zamaneh (2019). "The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis ". Journal of Cardiovascular Development and Disease 6 (4): 35. doi:10.3390/jcdd6040035. ISSN 2308-3425.