Squamous-cell carcinoma

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Author: Mikael Häggström [note 1]
Squamous-cell carcinoma (SCC):


Use the location-specific article when applicable:

Microscopic evaluation

To support the diagnosis of a suspected squamous-cell carcinoma, immunohistochemistry can be used, including p63 and p40.

Degree of differentiation

Applicable to invasive SCC. edit

Further workup

Immunohistochemistry for p16 highly correlates with HPV infection, and is indicated mainly in cervical dysplasia, but also in SCC of other sites where HPV infection is more or less frequently implicated, including vagina, vulva, penis, anus, tonsil and other oropharyngeal locations.[2]


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. 1.0 1.1 1.2 Yanofsky, Valerie R.; Mercer, Stephen E.; Phelps, Robert G. (2011). "Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review ". Journal of Skin Cancer 2011: 1–13. doi:10.1155/2011/210813. ISSN 2090-2905. .
    -"This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."
  2. Erika M. Baardsen, D.O., Marilin Rosa, M.D.. Cervix - Premalignant / preinvasive lesions - H&E - HPV. Pathology Outlines. Last author update: 1 December 2017. Last staff update: 5 May 2021

Image sources