Squamous-cell carcinoma of the lung

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Author: Mikael Häggström [notes 1]
Squamous-cell carcinoma (SCC) of the lung:

Presentations

Microscopic examination

Typical squamous-cell carcinoma cells are large with abundant eosinophilic cytoplasm and large, often vesicular, nuclei.[1]

  • Squamous-cell carcinoma in a bronchial lavage, pap stain

  • Squamous-cell carcinoma in a lung biopsy

If uncertain, the most useful immunostains are:

  • p63: Where a positive stain (pictured) indicates SCC rather than adenocarcinoma or small-cell carcinoma.[notes 2]

  • TTF-1: Is almost always negative in squamous-cell carcinoma (as pictured, with positive staining in surrounding type II alveolar pneumocytes). In contrast, TTF-1 is generally positive adenocarcinomas and small-cell carcinomas.[2]

Further workup

Optionally, stain for GATA-3, where a negative tests confirms a primary SCC, whereas a positive finding indicates metastasis from a squamous-cell carcinoma of the skin.[3]

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. ↑ p63 can distinguish SCC from adenocarcinoma with 85% sensitivity, 95% specificity, 94.4% PPV, and 86.4% NPV, and distinguish SCC from small-cell carcinoma with 85% sensitivity, 100% specificity, 100% PPV, and 87% NPV. Reference:
    - Jafarian AH, Gharib M, Mohammadian Roshan N, Sherafatnia S, Omidi AA, Bagheri S (2017). "The Diagnostic Value of TTF-1, P63, HMWK, CK7, and CD56 Immunostaining in the Classification of Lung Carcinoma. ". Iran J Pathol 12 (3): 195-201. PMID 29531543. PMC: 5835366. Archived from the original. . 

Main page

References

  1. ↑ Dr Nicholas Turnbull, A/Prof Patrick Emanual (2014-05-03). Squamous cell carcinoma pathology. DermNetz.
  2. ↑ Jafarian AH, Gharib M, Mohammadian Roshan N, Sherafatnia S, Omidi AA, Bagheri S (2017). "The Diagnostic Value of TTF-1, P63, HMWK, CK7, and CD56 Immunostaining in the Classification of Lung Carcinoma. ". Iran J Pathol 12 (3): 195-201. PMID 29531543. PMC: 5835366. Archived from the original. . 
  3. ↑ . Stains & molecular markers - GATA3. PathologyOutlines. Topic Completed: 1 March 2018. Minor changes: 26 June 2020}}
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