Template:Table of causes of vacuolar interface dermatitis

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Causes of vacuolar interface dermatitis edit
Main conditions[1] Characteristics Micrograph Photograph
Generally/Not otherwise specified Typical findings, called "vacuolar interface dermatitis":[1]
  • Mild inflammatory cell infiltrate along the dermoepidermal junction (black arrow in image)
  • Vacuolization within the basal keratinocytes (white arrow in image)
  • Often necrotic, predominantly basal, individual keratinocytes, manifesting as colloid or Civatte bodies
Vacuolar interface dermatitis, annotated.jpg
Acute graft-versus-host-disease
  • Vacuolar alteration of various severity, from focal or diffuse vacuolation of the basal keratinocytes (grade I), to separation at the dermoepidermal junction (grade III)
  • Involvement of the hair follicle[1]
  • Rarely eosinophils[1]
Micrographs of grades of skin graft-versus-host-disease.jpg
Allergic drug reaction
  • Rarely involvement of hair follicles.[1]
  • Frequently eosinophils[1]
Spongiotic dermatitis from drug allergy.jpg
Lichen sclerosus Hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocytes.[2] Micrograph of lichen sclerosus.jpg
Erythema multiforme
Lupus erythematosis Typical findings in systemic lupus erythematosus:[3]
  • Fibrinoid necrosis at the dermoepidermal junction
  • Liquefactive degeneration and atrophy of the epidermis
  • Mucin deposition in the reticular dermis
  • Edema, small hemorrhages
  • Mild and mainly lymphocytic infiltrate in the upper dermis
  • Fibrinoid material in the dermis around capillary blood vessels, on collagen and in the interstitium
  • In non-bullous cases, perivascular and interstitial neutrophils are sometimes present in the upper dermis, with damage to blood vessels
Histopathology of systemic lupus erythematosus.jpg Butterfly rash of lupus erythematosus.jpg


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Unless else specified in boxes, reference is: Alsaad, K O (2005). "My approach to superficial inflammatory dermatoses ". Journal of Clinical Pathology 58 (12): 1233–1241. doi:10.1136/jcp.2005.027151. ISSN 0021-9746. 
  2. Lisa K Pappas-Taffer. Lichen Sclerosus. Medscape. Updated: May 17, 2018
  3. Mowafak Hamodat. Skin inflammatory (nontumor) > Lichenoid and interface reaction patterns > Lupus: systemic lupus erythematosus (SLE). PathologyOutlines. Topic Completed: 1 August 2011. Revised: 26 March 2019

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